ChemicalBook >> CAS DataBase List >>JH-VIII-49
JH-VIII-49
- CAS No.
- 2209084-73-9
- Chemical Name:
- JH-VIII-49
- Synonyms
- JH-VIII-49;Androst-5-en-3-amine, 17-(7-isoquinolinyl)-N,N-dimethyl-, (3β,17β)-
- CBNumber:
- CB24844925
- Molecular Formula:
- C30H40N2
- Molecular Weight:
- 428.66
- MDL Number:
- MOL File:
- 2209084-73-9.mol
Last updated:2025-04-17 18:22:24
JH-VIII-49 Chemical Properties,Uses,Production
Uses
JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518)[1][2].
IC 50
CDK8: 16 nM (IC50)
References
[1] Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
JH-VIII-49 Preparation Products And Raw materials
Raw materials
Preparation Products
JH-VIII-49 Suppliers
Global( 3)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 23393 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12000 | 58 |
| Supplier | Advantage |
|---|---|
| Henan Tianfu Chemical Co.,Ltd. | 55 |
| TargetMol Chemicals Inc. | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |
JH-VIII-49
Androst-5-en-3-amine, 17-(7-isoquinolinyl)-N,N-dimethyl-, (3β,17β)-
2209084-73-9