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Follicle stimulating hormone

Follicle stimulating hormone
Follicle stimulating hormone structure
CAS No.
9002-68-0
Chemical Name:
Follicle stimulating hormone
Synonyms
FSH;HFSH;pFSH;fsh-p;hebin;RAT FSH;prolanb;OVINE FSH;anthrogon;MONKEY FSH
CBNumber:
CB3134719
Molecular Formula:
NULL
Formula Weight:
0
MOL File:
Mol file

Follicle stimulating hormone Properties

storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, soluble
form 
white powder
Merck 
13,4249
NCI Dictionary of Cancer Terms
follitropin; FSH
EPA Substance Registry System
Gonadotropin, menopausal(9002-68-0)
SAFETY
  • Risk and Safety Statements
Hazard Codes  B
Safety Statements  22-24/25
WGK Germany  3
RTECS  LP6330000
10-21

Follicle stimulating hormone price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 869001-M Follicle Stimulating Hormone from sheep pituitary 9002-68-0 10ug-m $161 2019-12-02 Buy
Sigma-Aldrich 869001-M Follicle Stimulating Hormone from sheep pituitary 9002-68-0 50ug-m $494 2019-12-02 Buy
Sigma-Aldrich F8174 Follicle Stimulating Hormone from sheep pituitary 9002-68-0 1vl $498 2018-11-20 Buy
Sigma-Aldrich F2293 Follicle Stimulating Hormone from porcine pituitary 9002-68-0 5vl $1220 2018-11-20 Buy
Sigma-Aldrich F4021 Follicle Stimulating Hormone from human pituitary ~7,000 IU/mg (vs. W.H.O. reference preparation 83/575) 9002-68-0 .1mg $1580 2019-12-02 Buy

Follicle stimulating hormone Chemical Properties,Uses,Production

Description

Gonal-F was launched in Austria, Germany, Denmark, Ireland, Italy, Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The recombinant follicule stimulating hormone (recFSH) was produced by introducing the genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells. The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from contaminants in uroFSH and can be injectable.

Description

Puregon was launched in Denmark, Germany and the UK for ovulation induction in clomiphene-resistent anovulation and controlled ovarian hyperstimulation. Transfected Chinese hamster ovary cells with plasmids containing the genes encoding the α- and β-FSH subunits produced recFSH that was similar to uroFSH. In both cases (follitropin α and β) no antibody formation was detected, however, this form appeared to be more active than follitropin α in that there was a 25% greater pregnancy rate compared to uroFSH.

Chemical Properties

Solid; soluble in water.

Originator

Genzyme (Switzerland)

Originator

Organon (Netherlands)

Uses

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consi

Definition

A gonadotropic glycoprotein secreted by the anterior pituitary gland. It regulates the metabolic activity of the granulosa of the mammalian ovary; stimulates maturation of ovarian follicles, and production of estrogens. Spermatogenesis is partially under

brand name

Humegon (Organon); Pergonal (Serono).

Clinical Use

The gonadotropin follicle-stimulating hormones (FSH), follitropin alfa (Gonal-F) and follitropin beta (Follistim), are produced in the anterior lobe of the pituitary gland. FSH can function in two ways. On the one hand, it causes increased spermatogenesis in men. On the other hand, in concert with estrogen and luteinizing hormone (LH), it stimulates follicular growth and development in women. Consequently, FSH may be useful in the treatment of infertility. FSH is a member of a superfamily of proteins, all structurally related, which includes LH, chorionic gonadotropin, and thyroid-stimulating hormone (TSH).

Purification Methods

FSH is purified by Sephadex G100 gel filtration followed by carboxymethyl-cellulose with NH4OAc pH 5.5. The latter separates luteinising hormone from FSH. Its solubility in H2O is 0.5%. It has an isoelectric point of 4.5. A solution of 1mg in saline (100mL) can be kept at 60o for 0.5hour. Activity is retained in a solution at pH 7-8 for 0.5hour at 75o. The activity of a 50% aqueous EtOH solution is destroyed at 60o in 15minutes. [Bloomfield et al. Biochim Biophys Acta 533 371 1978, Hartree Biochem J 100 754 1966, Pierce & Parsons Ann Rev Biochem 50 465 1981.]

Follicle stimulating hormone Preparation Products And Raw materials

Raw materials

Preparation Products


Follicle stimulating hormone Suppliers

Global( 76)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1277 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
career henan chemical co
0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29643 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15880 69
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9848 79
Beijing HuaMeiHuLiBiological Chemical 010-56205725
010-65763397 waley188@sohu.com China 12341 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-58378339
025-57019371 sales@sunlidabio.com;sales@sunlidabio.com China 3815 55

View Lastest Price from Follicle stimulating hormone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-02-18 Follicle stimulating hormone
9002-68-0
US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

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