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ChemicalBook >> CAS DataBase List >>4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol

4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol

4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol Structure
4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol structure
CAS No.
2886717-70-8
Chemical Name:
4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol
Synonyms
DGKα-IN-8;4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol;3-Butyn-2-ol, 4-[3-[(8-chloro-1-methyl-1H-1,2,3-triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-
CBNumber:
CB314213226
Molecular Formula:
C23H19ClF3N5O
Molecular Weight:
473.88
MDL Number:
MOL File:
2886717-70-8.mol
Last updated:2025-10-28 16:00:23
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4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol Properties

Boiling point 674.579±55.00 °C(Press: 760.00 Torr)(predicted)
Density 1.385±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka 13.241±0.29(predicted)

4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol Chemical Properties,Uses,Production

Uses

DGKα-IN-8 (Example 51) is a DGKα inhibitor (IC50=22.491 nM; EC50=0.256 nM). DGKα-IN-8 can be used to study cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection[1].

References

[1] Julian A Codelli, et al. Diacylglyercol kinase modulating compounds. Patent WO2022271659A1.

4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from 4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DGKα-IN-8 pictures 2025-10-27 DGKα-IN-8
2886717-70-8
 US $0.00-0.00 / mg 10g TargetMol Chemicals Inc.
  • DGKα-IN-8 pictures
  • DGKα-IN-8
    2886717-70-8
  • US $0.00-0.00 / mg
  • TargetMol Chemicals Inc.
4-[3-[(8-Chloro-1-methyl-1H-[1,2,3]triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl-3-butyn-2-ol DGKα-IN-8 3-Butyn-2-ol, 4-[3-[(8-chloro-1-methyl-1H-1,2,3-triazolo[4,5-c]isoquinolin-5-yl)(2,2-difluoroethyl)amino]-5-fluorophenyl]-2-methyl- 2886717-70-8