(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone
- CAS No.
- 881639-98-1
- Chemical Name:
- (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone
- Synonyms
- G-06710-1;G1,Inhibitor,G-1,inhibit,G 1,Estrogen Receptor/ERR;1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)ethanone;1-((3aR,4S,9bS)-rel-4-(6-Bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)ethanone;(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone;Ethanone, 1-[(3aR,4S,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-, rel-
- CBNumber:
- CB32518964
- Molecular Formula:
- C21H18BrNO3
- Molecular Weight:
- 412.28
- MDL Number:
- MFCD16618392
- MOL File:
- 881639-98-1.mol
- MSDS File:
- SDS
(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone Properties
Boiling point | 529.6±50.0 °C(Predicted) |
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Density | 1.457±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≥41.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
form | crystalline solid |
pka | 1.20±0.40(Predicted) |
color | White to off-white |
FDA UNII | Y3V5BV7OKM |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08,GHS09 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H400-H372 | |||||||||
Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
NFPA 704 |
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(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10008933 | G-1 ≥98% | 881639-98-1 | 1mg | $33 | 2024-03-01 | Buy |
Cayman Chemical | 10008933 | G-1 ≥98% | 881639-98-1 | 5mg | $120 | 2024-03-01 | Buy |
Cayman Chemical | 10008933 | G-1 ≥98% | 881639-98-1 | 10mg | $223 | 2024-03-01 | Buy |
Cayman Chemical | 10008933 | G-1 ≥98% | 881639-98-1 | 25mg | $475 | 2024-03-01 | Buy |
TRC | G932035 | G-1 | 881639-98-1 | 5mg | $350 | 2021-12-16 | Buy |
(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone Chemical Properties,Uses,Production
Description
GPR30 is a transmembrane G protein-
Uses
G-1 is a potent and selective G protein-coupled estrogen receptor (GPER) agonist (Ki = 11 nM, EC50 = 2 nM); displays no activity at ERα and ERβ at concentrations up to 10 μM. Increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants (IC50 values are 0.7 and 1.6 nM respectively) in vitro. Blocks MCF-1 cell cycle progression at the G1 phase. Displays therapeutic effects in the mouse EAE model of multiple sclerosis.
Definition
ChEBI: 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone is a member of quinolines.
storage
Store at -20°C
References
[1]. bologa cg, revankar cm, young sm, et al. virtual and biomolecular screening converge on a selective agonist for gpr30. nat chem biol, 2006, 2(4): 207-212.
[2]. kang s, liu y, sun d, et al. chronic activation of the g protein-coupled receptor 30 with agonist g-1 attenuates heart failure. plos one, 2012, 7(10): e48185.
(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13183 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Shanghai fuxiang biotechnology co., ltd | 13611719524 | 2674347328@qq.com | China | 49 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |