Pioglitazone (potassium salt)
- CAS No.
- 1266523-09-4
- Chemical Name:
- Pioglitazone (potassium salt)
- Synonyms
- Pioglitazone potassium;Pioglitazone (potassium salt);potassium:5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidin-3-ide-2,4-dione
- CBNumber:
- CB32592012
- Molecular Formula:
- C19H21KN2O3S
- Molecular Weight:
- 396.55
- MDL Number:
- MOL File:
- 1266523-09-4.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| FDA UNII | X1ZX7RX9WU |
Pioglitazone (potassium salt) price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10028 | Pioglitazone (potassium salt) ≥98% | 1266523-09-4 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 10028 | Pioglitazone (potassium salt) ≥98% | 1266523-09-4 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 10028 | Pioglitazone (potassium salt) ≥98% | 1266523-09-4 | 10mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 10028 | Pioglitazone (potassium salt) ≥98% | 1266523-09-4 | 50mg | $427 | 2026-04-30 | Buy |
| aablocks | AA009BLU | Pioglitazone (potassium salt) ≥98% | 1266523-09-4 | 1mg | $32 | 2026-05-28 | Buy |
Pioglitazone (potassium salt) Chemical Properties, Uses, Production
Uses
Pioglitazone (U 72107) potassium is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium can be used in diabetes research[2][3][4].
in vivo
Pioglitazone potassium (oral gavage, 10 or 30 mg/kg, once daily, 14 days) can induce improvements in insulin resistance and diabetes that may be lipocalin-dependent in the liver but not in skeletal muscle[3].
Pioglitazone potassium (oral gavage, 10 mg/kg, once daily, 4 weeks) can significantly reduce body weight (BW), cardiac hypertrophy, elevated blood glucose levels and improve the associated dyslipidemia[4].
| Animal Model: | ob/ob and adipo-/- ob/ob mice with a C57Bl/6 background[3] |
| Dosage: | 10 or 30 mg/kg |
| Administration: | Oral gavage; once daily; 14 days |
| Result: | Showed no changes of serum-free fatty acid and triglyceride levels as well as adipocyte sizes in ob/ob and adipo-/- ob/ob C57BL/6 mice at 10 mg/kg but significantly reduced to a similar degree at 30 mg/kg. Also showed no changes of expressions of TNFα and resistin in adipose tissues of ob/ob and adipo-/- ob/ob mice at 10 mg/kg but decreased at 30 mg/kg. |
| Animal Model: | Male Wistar albino rats[4] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; once daily; 4 weeks |
| Result: | Decreased the elevated serum levels of both creatinine and creatine kinase-MB (CK-MB), TGF-β1 gene expression and regulated the expression of MMP-2/TIMP-2 system. |
IC 50
mouse PPARγ: 0.99 μM (EC50); h-PPARγ: 0.93 μM (EC50); hPPARδ: 43 μM (EC50); hPPARα: 100 μM (EC50); mouse PPARα: 100 μM (EC50)
References
[1] Kenji Kuwabara, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist,2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. J Pharmacol Exp Ther. 2004 Jun;309(3):970-7. DOI:10.1124/jpet.103.064659
[2] A Puddu, et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. DOI:10.1016/j.regpep.2012.05.089
[3] Naoto Kubota, et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. DOI:10.1074/jbc.M505649200
[4] Rania A Elrashidy, et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33. DOI:10.1177/1074248411431581
Pioglitazone (potassium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
Pioglitazone (potassium salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
