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ChemicalBook >> CAS DataBase List >>N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Structure
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide structure
CAS No.
289472-78-2
Chemical Name:
N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide
Synonyms
Bortezomib USP IMP I;Bortezomib USP Impurity I;Bortezomib (EP) Impurity E;SR-Isomer, Bortezomib Impurity E;Bortezomib USP Related Compoud I;Bortezomib Impurity 2 (S,R-Isomer);Bortezomib (1S,2R) Isomer Impurity;(R)-Hydroxy Des(boric Acid) BortezoMib;Bortezomib impurity 5/Bortezomib EP Impurity E;(S,R)-Bortezomib Hydroxyisopentyl Amide Analog
CBNumber:
CB32661929
Molecular Formula:
C19H24N4O3
Molecular Weight:
356.42
MDL Number:
MOL File:
289472-78-2.mol
Last updated:2023-05-15 10:43:55
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N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Properties

Boiling point 672.0±55.0 °C(Predicted)
Density 1.199±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 11.90±0.46(Predicted)
form Solid
color White to Off-White
FDA UNII G2KA73LG6T

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H935900 (R)-HydroxyDes(boricAcid)Bortezomib 289472-78-2 25mg $1455 2021-12-16 Buy
American Custom Chemicals Corporation CCH0032707 N-((S)-1-(((R)-1-HYDROXY-3-METHYLBUTYL)AMINO)-1-OXO-3-PHENYLPROPAN-2-YL)PYRAZINE-2-CARBOXAMIDE 95.00% 289472-78-2 5MG $498.71 2021-12-16 Buy
Alichem 289472782 N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide 289472-78-2 1g $768 2021-12-16 Buy
Chemenu CM168279 N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide 95%+ 289472-78-2 1g $893 2021-12-16 Buy
Crysdot CD11152976 N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide 95+% 289472-78-2 1g $947 2021-12-16 Buy
Product number Packaging Price Buy
H935900 25mg $1455 Buy
CCH0032707 5MG $498.71 Buy
289472782 1g $768 Buy
CM168279 1g $893 Buy
CD11152976 1g $947 Buy

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Chemical Properties,Uses,Production

Uses

(R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide synthesis

179324-69-7
289472-78-2
Synthesis of N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide from Bortezomib

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Preparation Products And Raw materials

Raw materials

Bortezomib

Preparation Products

N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11927 58
Guangzhou PI PI Biotech Inc +86-020-81716320 +86-13602409664 Sales@pipitech.com China 3635 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Jiangsu Vcare PharmaTech Co., Ltd. 025-58741518; 18013018875 sales@vcarepharmatech.com China 308 61
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 4979 50
Supplier Advantage
Standardpharm Co. Ltd. 		58
CR Corporation Lomited 		58
sgtlifesciences pvt ltd 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
China National Standard Pharmaceutical Corporation Limited 		58
Guangzhou PI PI Biotech Inc 55
J & K SCIENTIFIC LTD. 76
Jiangsu Vcare PharmaTech Co., Ltd. 61
BOC Sciences 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50

289472-78-2(N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide)Related Search:

2-PyrazinecarboxaMide, N,N',N''-[2,4,6-boroxintriyltris[[(1R)-3-Methylbutylidene]iMino[(1S)-2-oxo-1-(phenylMethyl)-2,1-ethanediyl]]]tris- BORTEZOMIB-PINANEDIOL Bortezomib Impurity 2 (Mixture of (1S,2R)-Isomer and (1R,2R)-Isomer) Bortezomib Impurity 1 (R,S-Isomer) Boronic acid, B-[(1S)-3-Methyl-1-[[(2R)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]butyl]-
BortezoMib IMpurity 2 (RR-IsoMer) 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- (S)-N-(1-AMino-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide ((R)-3-Methyl-1-((R)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid 2-PyrazinecarboxaMide, N-[(1S)-2-[[(1S)-1-hydroperoxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]-
((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxaMido)propanaMido)butyl)boronic acid N-((S)-1-(((S)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide

1of3

2-PyrazinecarboxaMide, N-[(1S)-2-[[(1R)-1-hydroxy-3-Methylbutyl]aMino]-2-oxo-1-(phenylMethyl)ethyl]- (R)-Hydroxy Des(boric Acid) BortezoMib (N-[(1R)-1-hydroxy-3-Methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninaMide Bortezomib Impurity 2 (SR-Isomer, Bortezomib Impurity E) SR-Isomer, Bortezomib Impurity E N-((S)-1-(((R)-1-Hydroxy-3-Methylbutyl)aMino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxaMide BortezoMib IMpurity 2 (SR-IsoMer, EP IMpurity E) Bortezomib Impurity 2 (S,R-Isomer) Bortezomib USP Related Compoud I N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazin Bortezomib (1S,2R) Isomer Impurity Bortezomib impurity 5/Bortezomib EP Impurity E Bortezomib USP IMP I Bortezomib (EP) Impurity E Bortezomib USP Impurity I Bortezomib Related Compund I/ (S,R)-Bortezomib Hydroxyisopentyl Amide Analog (Bortezomib Hydroxy S,R-Isomer Impurity) (S,R)-Bortezomib Hydroxyisopentyl Amide Analog N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide? (Bortezomib Impurity） 289472-78-2