MK 6096
- CAS No.
- 1088991-73-4
- Chemical Name:
- MK 6096
- Synonyms
- MK6096;MK-6096;CS-1825;MK 6096;Filorexant;MK 6096;MK6096;Filorexant(MK-6096);MK-6096(Filorexant);filorexant / MK-6096, CID25128145;Inhibitor,inhibit,MK 6096,Orexin Receptor (OX Receptor),MK6096,Filorexant,Hypocretin Receptor,HCRT Receptor
- CBNumber:
- CB32666757
- Molecular Formula:
- C24H25FN4O2
- Molecular Weight:
- 420.48
- MDL Number:
- MFCD28100674
- MOL File:
- 1088991-73-4.mol
- MSDS File:
- SDS
| Boiling point | 540.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.203±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 2mg/mL; Ethanol: 5mg/mL |
| form | A solid |
| pka | 1.54±0.22(Predicted) |
| FDA UNII | E6BTT8VA5Z |
MK 6096 price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29490 | Filorexant | 1088991-73-4 | 25mg | $421 | 2024-03-01 | Buy |
| Cayman Chemical | 29490 | Filorexant | 1088991-73-4 | 50mg | $629 | 2024-03-01 | Buy |
| Cayman Chemical | 29490 | Filorexant | 1088991-73-4 | 5mg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 29490 | Filorexant | 1088991-73-4 | 10mg | $253 | 2024-03-01 | Buy |
| TRC | F337008 | Filorexant | 1088991-73-4 | 5mg | $140 | 2021-12-16 | Buy |
MK 6096 Chemical Properties,Uses,Production
Description
Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 2.5 and 0.31 nM, respectively, for the recombinant human receptors). It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (Kb = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.
Uses
Filorexant is a selective dual orexin receptor antagonist with potent sleep-promoting properties. It has advanced into phase II clinical trials for the treatment of insomnia.
MK 6096 Preparation Products And Raw materials
Raw materials
Preparation Products
MK 6096 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |