ChemicalBook >> CAS DataBase List >>VRT-1353385
VRT-1353385
- CAS No.
- 1616113-45-1
- Chemical Name:
- VRT-1353385
- Synonyms
- EB8018;CS-1707;Sibofimloc;VRT-1353385;Antibiotic-202;VRT 1353385;VRT1353385;Sibofimloc, 10 mM in DMSO;Antibiotic 202, Sibofimloc;Antibiotic-202, VRT-1353385;Sibofimloc (VRT-1353385, Antibiotic-202)
- CBNumber:
- CB32741568
- Molecular Formula:
- C35H39NO11
- Molecular Weight:
- 649.68
- MDL Number:
- MOL File:
- 1616113-45-1.mol
Last updated:2025-12-05 14:33:18
| Product description | Number | Pack Size | Price |
| Sibofimloc 98.62% | CS-5487 | 5mg | $105 |
| Sibofimloc 98.62% | CS-5487 | 10mg | $180 |
| Sibofimloc 98.62% | CS-5487 | 50mg | $450 |
| Sibofimloc 98.62% | CS-5487 | 100mg | $750 |
| VRT-1353385 >98% | DC8047 | 250mg | $1500 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | ≥ 20.2mg/mL in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | 00OF00QZC4 |
VRT-1353385 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5487 | Sibofimloc 98.62% | 1616113-45-1 | 5mg | $105 | 2021-12-16 | Buy |
| ChemScene | CS-5487 | Sibofimloc 98.62% | 1616113-45-1 | 10mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-5487 | Sibofimloc 98.62% | 1616113-45-1 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-5487 | Sibofimloc 98.62% | 1616113-45-1 | 100mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC8047 | VRT-1353385 >98% | 1616113-45-1 | 250mg | $1500 | 2021-12-16 | Buy |
VRT-1353385 Chemical Properties,Uses,Production
Uses
Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2].
References
[1] Ramtohul, Yeeman K, et al. Preparation of mannose derivatives via coupling and click cycloaddition reactions for treating bacterial infections. From PCT Int. Appl. (2014), WO 2014100158 A1 20140626.
[2] W Reinisch, et al. P568 An open-label, multicenter, phase ib, pharmacokinetic (pk) and safety study of a fimh blocker, Sibofimloc (TAK-018/EB8018), in patients with Crohn’s disease (CD), Journal of Crohn's and Colitis, Volume 14, Issue Supplement_1, January 2020: S479–S480.
VRT-1353385 Preparation Products And Raw materials
Raw materials
Preparation Products
VRT-1353385 Suppliers
Global( 59)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8510 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; | sales@sun-shinechem.com | China | 1077 | 64 |
View Lastest Price from VRT-1353385 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-05 | Sibofimloc
1616113-45-1
|
US $33.00-129.00 / mg | 99.11% | 10g | TargetMol Chemicals Inc. |
-
- Sibofimloc
1616113-45-1
- US $33.00-129.00 / mg
- 99.11%
- TargetMol Chemicals Inc.
VRT-1353385
Antibiotic-202
8,8'-(1'-Acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-D-glycero-D-manno-oct-7-ynitol]
1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone
VRT 1353385;VRT1353385
1-(2,7-bis(((2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)-1'l4-spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one
Antibiotic-202, VRT-1353385
CS-1707
Sibofimloc
1-[2,7-bis[2-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]ethynyl]spiro[fluorene-9,4'-piperidine]-1'-yl]ethanone
Antibiotic 202, Sibofimloc
D-glycero-D-manno-Oct-7-ynitol, 8,8'-(1'-acetylspiro[9H-fluorene-9,4'-piperidine]-2,7-diyl)bis[2,6-anhydro-7,8-dideoxy-
EB8018
disease,Sibofimloc,Crohn's,bowel,Antibiotic202,Bacterial,IBD,inhibit,colitis,inflammatory,Antibiotic,Inhibitor,ulcerative
1-(2,7-Bis(((2R,3S,4R,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one
Sibofimloc, 10 mM in DMSO
Sibofimloc (VRT-1353385, Antibiotic-202)
1-(2,7-Bis(((2R,3S,4R,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)ethynyl)spiro[fluorene-9,4'-piperidin]-1'-yl)ethan-1-one
1616113-45-1
C35H39NO11
