N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
- CAS No.
- 1215703-04-0
- Chemical Name:
- N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
- Synonyms
- BMS182874;BMS-182874 hydrochloride >=98% (HPLC);N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride
- CBNumber:
- CB32750685
- Molecular Formula:
- C17H20ClN3O3S
- Molecular Weight:
- 381.88
- MDL Number:
- MOL File:
- 1215703-04-0.mol
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride price More Price(5)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0708 | BMS-182874 hydrochloride ≥98% (HPLC) | 1215703-04-0 | 5mg | $106 | 2022-05-15 | Buy |
Sigma-Aldrich | SML0708 | BMS-182874 hydrochloride ≥98% (HPLC) | 1215703-04-0 | 25mg | $416 | 2022-05-15 | Buy |
TRC | B695565 | BMS-182874 hydrochloride | 1215703-04-0 | 5mg | $385 | 2021-12-16 | Buy |
ApexBio Technology | B5113 | BMS-182874 hydrochloride | 1215703-04-0 | 50mg | $1362 | 2021-12-16 | Buy |
ApexBio Technology | B5113 | BMS-182874 hydrochloride | 1215703-04-0 | 10mg | $329 | 2021-12-16 | Buy |
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Chemical Properties,Uses,Production
Biological Activity
ki: 61 nm for eta in vsm-a10 cells; 48 nm for eta in cho cellsendothelin (et) was originally identified as a potent vasoactive substance secreted by endothelial cells that stimulated force development in isolated pig coronary arteries. et-1 belongs to a family of highly conserved 21-amino-acid peptides produced in numerous tissues including the lung, kidney, eye, gut and central nervous system. bms-182874 is a low molecular weight, nonpeptide endothelin (el) receptor antagonist.
in vitro
bms-182874 competitively inhibited the binding of [125i]et-1 to eta receptors in rat vascular smooth muscle a10 (vsm-a10) cell membranes (ki = 61 nm) and in cho cells stably expressing the human eta receptor (ki = 48 nm), but was a weak inhibitor at etb receptors (ki > 50 μm) and non-et receptors. bms-l 82874 inhibited et-l -stimulated inositol phosphate accumulation (kb 75 nm) and calcium mobilization (ki = 140 nm) without suppressing the maximal responses in vsm-a10 cells [1].
in vivo
when administered either orally (ed50 = 30 μmol/kg) or intravenously (ed50 = 24 μmol/kg) to conscious, normotensive rats, bms-182874 blunted the pressor response to exogenous et-l . these data demonstrate that bms-l 82874 is a competitive, selective and orally active eta receptor antagonist [1].
References
[1] maria l webb, j. eileen bird, eddie c. k. liu, patricia m. rose, randy serafino, philip d. stein and suzanne moreland. bms-182874 is a selective, nonpeptide endothelin eta receptor antagonist. jpet 272:1124-1134, 1995.
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9737 | 58 |
Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
Hangzhou Molot Chemical Technology Co., Ltd. | 0571-56906266 17706505167 | sales@morotchem.com | China | 500 | 58 |
ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3696 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |