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1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER structure

CAS No.: 301226-25-5

Chemical Name:: 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Synonyms: 1-Oxa-5-azaspiro[2.4];5-Boc-1-oxa-5-azaspiro[2.4]heptane;tert-Butyl 1-oxa-5-azaspiro[2,4]heptane-5-carboxyate;tert-Butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate;tert-Butyl 2-oxa-6-azaspiro[2.4]heptane-6-carboxylate;tert-butyl 1-oxa-6-azaspiro[2.4]heptane-6-carboxylate;1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester;2-oxa-6-azaspiro[2.4]heptane-6-carboxylic acid tert-butyl ester;rac-1-oxa-5-aza-spiro[2.4]heptane-5-carboxylic acid tert-butyl ester;1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester - X6275

CBNumber:: CB3277544

Molecular Formula:: C10H17NO3

Molecular Weight:: 199.25

MDL Number:: MFCD07779387

MOL File:: 301226-25-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

Product description	Number	Pack Size	Price
1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester Aldrich	SYX00237	1g	$861
tert-Butyl1-Oxa-5-azaspiro[2.4]heptane-5-carboxylate	B809733	50mg	$60
3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane	4H56-1-PH	250mg	$125
3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane	4H56-1-PH	1g	$375
1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester 96%	070749	1g	$500
More product size

Request For Quotation

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
form	liquid
color	Light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H412
Precautionary statements	P264-P270-P273-P301+P312-P501
Hazard Codes	T
Risk Statements	52
WGK Germany	3
HS Code	2934999090

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00237	1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester Aldrich	301226-25-5	1g	$861	2023-01-07	Buy
TRC	B809733	tert-Butyl1-Oxa-5-azaspiro[2.4]heptane-5-carboxylate	301226-25-5	50mg	$60	2021-12-16	Buy
SynQuest Laboratories	4H56-1-PH	3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane	301226-25-5	250mg	$125	2021-12-16	Buy
SynQuest Laboratories	4H56-1-PH	3-Boc-6-oxa-3-azabicyclo[3.1.0]hexane	301226-25-5	1g	$375	2021-12-16	Buy
Matrix Scientific	070749	1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester 96%	301226-25-5	1g	$500	2021-12-16	Buy

Product number	Packaging	Price	Buy
SYX00237	1g	$861	Buy
B809733	50mg	$60	Buy
4H56-1-PH	250mg	$125	Buy
4H56-1-PH	1g	$375	Buy
070749	1g	$500	Buy

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Uses,Production

Uses

tert-butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate is ureful reactant for the synthesis of spirocyclic-3,4-dihydro-2H-benzo[b][1,4]oxazine derivatives.

Synthesis

tert-butyl 3-Methylenepyrrolidine-1-carboxylate

114214-71-0

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

301226-25-5

At room temperature, tert-butyl 3-methylene pyrrolidine-1-carboxylate (195 mg, 1.06 mmol) was dissolved in dichloromethane (5 mL), followed by the addition of m-chloroperoxybenzoic acid (mCPBA, 275 mg, 1.60 mmol). The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution (2 mL) and then the organic phase was extracted with ethyl acetate (60 mL). The organic phase was washed sequentially with water and brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting crude product was purified by fast silica gel column chromatography with the eluent being a hexane solution of 25% ethyl acetate to afford tert-butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate (150 mg, 0.753 mmol, 71% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 3.91-3.42 (m, 3H), 3.48-3.16 (m, 1H), 2.93 (s, 2H), 2.35-2.17 (m, 1H), 1.93-1.79 (m, 1H), 1.47 (s, 9H).

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 21, p. 9738 - 9755
[2] Patent: WO2015/35278, 2015, A1. Location in patent: Page/Page column 89
[3] Patent: US2017/233339, 2017, A1

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

tert-butyl 3-Methylenepyrrolidine-1-carboxylate Dichloromethane 3-Chloroperoxybenzoic acid

Preparation Products

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Suppliers

Global( 67)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9653	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8618662433356	3899766280@qq.com	China	26362	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Young Lively PharminBlock Co.,Ltd	+undefined18600731423	jason_gao@yl-pharminblock.com	China	1944	58
Suzhou ARTK Medchem Co., Ltd.	+8618118463618	sales1@artkmedchem.com	China	39021	58

Supplier	Advantage
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
changzhou huayang technology co., ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	58
Henan Fengda Chemical Co., Ltd	58
Young Lively PharminBlock Co.,Ltd	58
Suzhou ARTK Medchem Co., Ltd.	58

View Lastest Price from 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 301226-25-5	US $1.00 / KG	1KG	99%	20kg	Career Henan Chemical Co

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
301226-25-5
US $1.00 / KG
99%
Career Henan Chemical Co

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Spectrum

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER(301226-25-5)¹HNMR

301226-25-5(1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER)Related Search:

1-BOC-3-METHOXYPYRROLIDINE TERT-BUTYL N-(2-OXIRANYLMETHYL)CARBAMATE 1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

1-OXA-5-AZASPIRO[2.4]HEPTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER tert-Butyl 1-oxa-5-azaspiro[2.4]heptane-5-carboxylate tert-Butyl 1-oxa-5-azaspiro[2,4]heptane-5-carboxyate 1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester tert-butyl 1-oxa-6-azaspiro[2.4]heptane-6-carboxylate tert-Butyl 2-oxa-6-azaspiro[2.4]heptane-6-carboxylate 2-oxa-6-azaspiro[2.4]heptane-6-carboxylic acid tert-butyl ester 1-Oxa-5-azaspiro[2.4] 1-Oxa-5-azaspiro[2.4]heptane-5-carboxylic acid tert-butyl ester - X6275 rac-1-oxa-5-aza-spiro[2.4]heptane-5-carboxylic acid tert-butyl ester 5-Boc-1-oxa-5-azaspiro[2.4]heptane 301226-25-5