TIEMONIUM IODIDE
- CAS No.
- 144-12-7
- Chemical Name:
- TIEMONIUM IODIDE
- Synonyms
- te114;114c.e.;tiemozyl;cerfa114;Tiemonium;visceralgin;Visceralgina;Visceralgine;TIEMONIUM IODIDE;Thiemonium iodide
- CBNumber:
- CB3365056
- Molecular Formula:
- C18H24INO2S
- Molecular Weight:
- 445.36
- MDL Number:
- MFCD00274608
- MOL File:
- 144-12-7.mol
- MSDS File:
- SDS
| Melting point | 189-191° |
|---|---|
| FDA UNII | FZ2LZ7U304 |
| ATC code | A03AB17 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
TIEMONIUM IODIDE price More Price(1)
TIEMONIUM IODIDE Chemical Properties,Uses,Production
Originator
Visceralgine,Riom,France,1963
Uses
Thiemonium Iodide is found in compositions containing bicifadine for the treatment of urinary incontinence.
Definition
ChEBI: Tiemonium iodide is an aralkylamine.
Manufacturing Process
(a) N-(3-hydroxy-3-phenyl-3-α-thienyl-propyl) morpholine was first prepared:
The following quantities of reactants were mixed in a 2-liter balloon flask
having 3 tubes fitted respectively with a mercury-sealed agitator, a reflux
condenser having a calcium chloride seal, and a dropping funnel:
Magnesium turnings 27 g (1.1 g at. wt)
Bromobenzene 181 g (1.15 mol)
Anhydrous ether 500 cc
(b) To the cold Grignard solution was added a solution containing:
Thienyl-morpholinoethyl ketone 180 g (0.8 mol)
Anhydrous ether 250 cc
The ketone, preferably prepared by a Grignard reaction, was added in such a
way as to maintain the ether under constant reflux. When all of the solution
had been added, the mixture was refluxed for a further hour. The mixture was
then allowed to stand for 12 hours at ambient temperature, after which the
reaction mass was extracted with ice and ammonium chloride in known
manner.
(c) The ether solution was treated with 2 N hydrochloric acid solution and the
amino-alcohol was obtained as the hydrochloride (yield approximately 60%);
it was purified by recrystallization from methanol.
The resulting product was dissolved in water, made alkaline with dilute
NH4OHand was extracted with ether. After evaporation of the ether, the
amino-alcohol was obtained as a base.
(d) To prepare the quaternary ammonium iodide, the amino-alcohol above
was dissolved in a minimum amount of anhydrous ether and was treated with
its own weight of methyl iodide. A well-crystallized product was obtained and
was washed with anhydrous ether. (Melting point 189°C to 191°C).
Therapeutic Function
Spasmolytic, Anticholinergic
TIEMONIUM IODIDE Preparation Products And Raw materials
TIEMONIUM IODIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 2929 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27644 | 58 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9947 | 58 |
| Pushan Industry (Shaanxi) Co., Ltd. | 029-81310890 13571859809 | info@pushanshiye.com | China | 10005 | 58 |
View Lastest Price from TIEMONIUM IODIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-20 | TIEMONIUM IODIDE
144-12-7
|
US $1.00-1.00 / Kg/Bag | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2021-06-11 | TIEMONIUM IODIDE USP/EP/BP
144-12-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- TIEMONIUM IODIDE
144-12-7
- US $1.00-1.00 / Kg/Bag
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- TIEMONIUM IODIDE USP/EP/BP
144-12-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited