ChemicalBook >> CAS DataBase List >>Bromobenzene


Chemical Name:
1-Bromobenzene;Brombenzol;PHENYL BROMIDE;4-Bromobenzene;NCI-C55492;Bromobenzol;BROMOBENZENE;bromo-benzen;Benzene,bromo-;Bromobenzene 1
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2023-04-23

Bromobenzene Properties

Melting point -31 °C
Boiling point 156 °C(lit.)
Density 1.491 g/mL at 25 °C(lit.)
vapor density 5.41 (vs air)
vapor pressure 10 mm Hg ( 40 °C)
refractive index n20/D 1.559(lit.)
Flash point 124 °F
storage temp. Store below +30°C.
solubility Miscible with diethyl ether, alcohol, carbon tetrachloride, chloroform and benzene.
form Liquid
color Clear colorless to faintly yellow
Odor pleasant smell
explosive limit 0.5-2.5%(V)
Water Solubility insoluble. <0.1 g/100 mL at 20.5 ºC
Merck 14,1406
BRN 1236661
Henry's Law Constant 2.47 at 25 °C (gas stripping-GC, Shiu and Mackay, 1997)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
LogP 3.14 at 25℃
CAS DataBase Reference 108-86-1(CAS DataBase Reference)
EWG's Food Scores 2
NIST Chemistry Reference Benzene, bromo-(108-86-1)
EPA Substance Registry System Bromobenzene (108-86-1)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word  Warning
Hazard statements  H226-H315-H411
Precautionary statements  P210-P273-P302+P352
Hazard Codes  Xi,N,F,T
Risk Statements  10-38-51/53-39/23/24/25-23/24/25
Safety Statements  61-45-36/37
RIDADR  UN 2514 3/PG 3
WGK Germany  2
RTECS  CY9000000
Autoignition Temperature 565 °C
HS Code  2903 99 80
HazardClass  3
PackingGroup  III
Toxicity LD50 orally in Rabbit: 2383 mg/kg
NFPA 704
1 0

Bromobenzene price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.01786 Bromobenzene for synthesis 108-86-1 5ml $28.7 2023-01-07 Buy
Sigma-Aldrich 8.01786 Bromobenzene for synthesis 108-86-1 250ML $34.3 2023-01-07 Buy
Sigma-Aldrich 8.01786 Bromobenzene for synthesis 108-86-1 1L $130 2023-01-07 Buy
Sigma-Aldrich 8.01786 Bromobenzene for synthesis 108-86-1 25L $3050 2023-01-07 Buy
Sigma-Aldrich 16350 Bromobenzene ≥99.5% (GC) 108-86-1 100ml $42 2023-01-07 Buy
Product number Packaging Price Buy
8.01786 5ml $28.7 Buy
8.01786 250ML $34.3 Buy
8.01786 1L $130 Buy
8.01786 25L $3050 Buy
16350 100ml $42 Buy

Bromobenzene Chemical Properties,Uses,Production

Chemical Properties

Bromobenzene, also known as phenyl bromide and monobromobenzene, is a benzene halogen derivative generated by benzene being substituted by bromine in the presence of iron powder. The chemical reaction principle is the same as that of chlorination of benzene to produce chlorobenzene. The reaction between bromobenzene and metal magnesium can generate phenylmagnesium bromide, which is a Grignard reagent with important uses in organic synthesis.

Physical properties

Mobile, clear, colorless to pale yellow liquid with an aromatic odor. The reported odor threshold is 4.6 ppm (Mateson, 1955). Insoluble in water, soluble in benzene, alcohol, ether, chlorobenzene and other organic solvents. It is irritating to the skin and anesthetic to the nerves. Its toxicity is stronger than chlorobenzene. Inhalation of its vapors can cause anemia and damage the liver.


Bromobenzene is a colorless, flammable liquid with a density greater than water and with an aromatic odor. It is synthesized by the reaction of bromide with benzene in the presence of iron powder. It is used for organic synthesis, particularly in the production of the intermediate phenylmagnesium bromide. Bromobenzene is an additive to motor oils and used as a crystallizing solvent. It is used as an ingredient in the manufacture of phencyclidine, a recreational drug.


Bromobenzene is obtained by reacting benzene with bromine. First add iron powder and benzene into the reactor, slowly add bromine under stirring, keep the reaction at 70-80°C for 1 h after adding, the obtained crude product is washed with water and 5% sodium hydroxide solution, left to stand for stratification, distillation, Drying, filtering, and finally fractional distillation under constant pressure, taking the fraction at 155-157°C to obtain the finished product.


The compound is employed as a starting material in organic syntheses in which a Grignard intermediate (phenyl magnesium bromide) is used. The material is a chemical precursor for certain agricultural products and has been used as an additive to motor oils. Bromobenzene has also been used as a high-density solvent for chemical recrystallization processes. especially for crystallizations on a large scale and where a heavy liquid is desirable.


ChEBI: Bromobenzene is the simplest member of the class of bromobenzenes, that is benzene in which a single hydrogen has been substituted by a bromine. A liquid at room temperature (m.p. -30℃; b.p.760 156℃), it is used as a solvent, particularly for large-scale crystallisations, and for the introduction of phenyl groups in organic synthesis. It has a role as a non-polar solvent, a hepatotoxic agent and a mouse metabolite. It is a member of bromobenzenes, a bromoarene and a volatile organic compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 304, 1965 DOI: 10.1021/jo01012a512
Tetrahedron Letters, 26, p. 1935, 1985 DOI: 10.1016/S0040-4039(00)98345-X

General Description

Mobile clear colorless liquid with a pungent odor. Flash point 124°F. Denser than water and insoluble in water. Hence sinks in water. Vapors are heavier than air. A skin irritant.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

Bromobenzene may be sensitive to light. May react with oxidizing agents .

Health Hazard

Contact with liquid causes irritation of eyes and mild irritation of skin. Ingestion causes mild irritation of mouth and stomach.

Fire Hazard

Moderate fire risk. Special Hazards of Combustion Products: Irritating hydrogen bromide and other gases may be produced in fire.

Biochem/physiol Actions

Bromobenzene induces hepatic necrosis via the formation of a reactive metabolite that arylates vital cellular macromolecules.

Safety Profile

Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. LWdly toxic by inhalation. An eye and mucous membrane irritant. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. Can react with oxidtzing materials. To fight fire, use water to blanket fire, foam, CO2, water spray or mist, dry chemical. Violent reaction with bromobutane + sodium when heated above 30℃. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.


No MCLs, MCLGs, or DWELs have been proposed (U.S. EPA, 2000).
Storm water runoff, waste motor oils, improper disposal of laboratory solvent containing bromobenzene (quoted, Verschueren, 1983)

Environmental Fate

Bromobenzene will volatilize from dry surfaces, due to its vapor pressure of 4.18mmHg at 25°C, and therefore will exist as a vapor in the environment. Bromobenzene will undergo little hydrolysis in water and little biodegradation by aquatic microorganisms. Bromobenzene is not expected to adsorb to sediment from water due to its soil sorption constant (Koc) of 150 and water solubility of 446 mg l-1. It is also expected to have a high mobility in soil and volatilize easily from moist surfaces due to its Henry’s law constant of 2.47×10-3 atmm3 mol-1 at 25°C. Bioconcentration factors range from low values of 8.8 in carp to moderately high values of 190 in algae.

Metabolic pathway

Bromobenzene and chlorobenzene are metabolized by human and mouse hepatic microsomes to two different epoxide intermediates, which rearrange to form either o- or p-bromo- and o- or p-chlorophenols, respectively. Humans preferentially metabolize halobenzenes through the hepatotoxic 3,4-epoxide pathway, suggesting that humans may be more susceptible than mice to halobenzene-induced hepatotoxicity.

Purification Methods

Wash bromobenzene vigorously with conc H2SO4, then 10% NaOH or NaHCO3 solutions, and H2O. Dry it with CaCl2 or Na2SO4, or pass it through activated alumina, before refluxing with, and distilling from, CaH2, using a glass helix-packed column. [Beilstein 5 IV 670.]


The acute toxicity of bromobenzene is lowin test animals. The toxic symptoms includesomnolence, respiratory stimulation, and muscle contraction. The oral LD50 value in rats is2700 mg/kg.

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View Lastest Price from Bromobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bromobenzene pictures 2023-05-24 Bromobenzene
US $15.00 / kg 1kg 99 10000 kilograms/month Hebei Yime New Material Technology Co., Ltd.
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Bromobenzene pictures 2023-04-26 Bromobenzene
US $10.00-100.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
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