2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide
- CAS No.
- 159883-95-1
- Chemical Name:
- 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide
- Synonyms
- 2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide;1H-Indole-3-acetamide, 1-(2,2-diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-, (+)-
- CBNumber:
- CB33796745
- Molecular Formula:
- C31H36N4O5
- Molecular Weight:
- 544.64
- MDL Number:
- MOL File:
- 159883-95-1.mol
2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Properties
Melting point | 100-102 °C |
---|---|
Boiling point | 766.6±60.0 °C(Predicted) |
Density | 1.25±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | ≤5mg/ml in DMSO;10mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 10.31±0.20(Predicted) |
2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 10010129 | AG-041R ≥98% | 159883-95-1 | 1mg | $45 | 2024-03-01 | Buy |
Cayman Chemical | 10010129 | AG-041R ≥98% | 159883-95-1 | 5mg | $198 | 2024-03-01 | Buy |
Cayman Chemical | 10010129 | AG-041R ≥98% | 159883-95-1 | 10mg | $351 | 2024-03-01 | Buy |
Cayman Chemical | 10010129 | AG-041R ≥98% | 159883-95-1 | 50mg | $1528 | 2024-03-01 | Buy |
ApexBio Technology | C4101 | AG-041R | 159883-95-1 | 50mg | $1746 | 2021-12-16 | Buy |
2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Chemical Properties,Uses,Production
Biological Activity
ag-041r is a cholecystokinin-b/gastrin receptor (gastrin/cck-b) antagonist [1]. the gastrin/cck-b receptor is a regulator of gastric acid secretion and mucosal growth. the gastrin/cck-b is abundantly expressed in mammalian stomach [2].
in vitro
in rabbit primary chondrocytes, ag-041r (0.1 μm) stimulated the cell growth and proliferation, but suppressed with 10 μm. treatment with ag-041r (1 μm) for 28 days accelerated the chondrocyte growth and increased the cell number [1]. in chondrocytes incubated with 0.1 and 1 μm ag-041r, synthesis of gag increased with culture, and amounts accumulated in the composites increased [1]. 10 μm ag-041r might be even toxic to the cells and total rna levels [1]. the ratio of the amounts of two chondroitin sulfate isomers, chondroitin-6-sulfate to chondroitin-4-sulfate, an indicator of cartilage maturation, increased with 1 μm but decreased with 10 μm ag-041r [1].
in vivo
in a preclinical toxicological study on rats, oral administration of high dose of ag-041r stimulated systemic cartilage hyperplasia, including the trachea, the intervertebral disk and the articular cartilage. daily intraarticular injection of ag-041r for 3 weeks into rat knee joints also induced cartilage hyperplasia in marginal regions of the femoral condyle without affecting other tissues [1].
References
[1] ochi m, kawasaki k, kataoka h, et al. ag-041r, a gastrin/cck-b antagonist, stimulates chondrocyte proliferation and metabolism in vitro[j]. biochemical and biophysical research communications, 2001, 283(5): 1118-1123.
[2] langhans n, rindi g, chiu m, et al. abnormal gastric histology and decreased acid production in cholecystokinin-b/gastrin receptor-deficient mice[j]. gastroenterology, 1997, 112(1): 280-286.
2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(3R)-1-(2,2-diethoxyethyl)-3-[(4-methylphenyl)carbamoylamino]-2-oxoindol-3-yl]-N-(4-methylphenyl)acetamide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Shanghai EFE Biological Technology Co., Ltd. | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
ApexBio Technology | 58 |