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Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)

CAS No.
2021249-10-3
Chemical Name:
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
Synonyms
Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
CBNumber:
CB34797732
Molecular Formula:
C44H49Cl2NO7
Molecular Weight:
774.78
MDL Number:
MOL File:
2021249-10-3.mol
Last updated:2023-04-23 13:52:06

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Properties

solubility DMF: soluble; DMSO: soluble; Methanol: soluble
form A solid

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30813 Vilanterol-d4 (triphenylacetate) 2021249-10-3 500μg $303 2024-03-01 Buy
Cayman Chemical 30813 Vilanterol-d4 (triphenylacetate) 2021249-10-3 1mg $576 2024-03-01 Buy
Product number Packaging Price Buy
30813 500μg $303 Buy
30813 1mg $576 Buy

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties,Uses,Production

Description

Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

References

1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: An antedrug approach J. Med. Chem. 53(11),4522-4530(2010).

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials

Raw materials

Preparation Products

Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Suppliers

Global( 11)Suppliers
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Vilanterol-d4 Triphenylacetate Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate 2021249-10-3