Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
- CAS No.
- 2021249-10-3
- Chemical Name:
- Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate)
- Synonyms
- Vilanterol-d4 Triphenylacetate;Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate);α1R-[[[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy-d4]hexyl]amino]methyl]-4-hydroxy-1,3-benzenedimethanol, triphenylacetate
- CBNumber:
- CB34797732
- Molecular Formula:
- C44H49Cl2NO7
- Molecular Weight:
- 774.78
- MDL Number:
- MOL File:
- 2021249-10-3.mol
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) price More Price(2)
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Chemical Properties,Uses,Production
Description
Vilanterol-d4 is intended for use as an internal standard for the quantification of vilanterol by GC- or LC-MS. Vilanterol is a long-acting agonist of the β2-adrenergic receptor (β2-AR).1 It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50 = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine in guinea pigs when administered via nebulization (EC50 = 30 μM). Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.
References
1. Procopiou, P.A., Barrett, V.J., Bevan, N.J., et al. Synthesis and structure-
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Preparation Products And Raw materials
Raw materials
Preparation Products
Vilanterol Impurity 22(Vilanterol-d4 Triphenylacetate) Suppliers
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