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Vilanterol Trifenatate

CAS No.
503070-58-4
Chemical Name:
Vilanterol Trifenatate
Synonyms
vilanterol trifenatate;Vilanterol Trifenate;Vilanterol triphenylacetate;GW642444M;GW 642444M;GW-642444M;GW642444M Trifenate;GW642444 (trifenatate);Vilanterol Trifenatate (API);GW642444M; GW 642444M; GW-642444M
CBNumber:
CB32563287
Molecular Formula:
C44H49Cl2NO7
Molecular Weight:
774.78
MDL Number:
MFCD28978327
MOL File:
503070-58-4.mol
MSDS File:
SDS
Last updated:2024-03-11 17:00:25

Vilanterol Trifenatate Properties

Melting point 131.9-134.2℃
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Dichloromethane (Slightly), Methanol (Slightly)
form Solid
color White to Off-White
Stability Hygroscopic
FDA UNII 40AHO2C6DG

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Vilanterol Trifenatate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3389 Vilanterol trifenatate ≥95% (HPLC) 503070-58-4 10MG $86.5 2024-03-01 Buy
Sigma-Aldrich SML3389 Vilanterol trifenatate ≥95% (HPLC) 503070-58-4 50MG $350 2024-03-01 Buy
TRC V260000 VilanterolTrifenatate 503070-58-4 5mg $225 2021-12-16 Buy
ChemScene CS-1679 Vilanterol(trifenatate) 99.20% 503070-58-4 5mg $100 2021-12-16 Buy
ChemScene CS-1679 Vilanterol(trifenatate) 99.20% 503070-58-4 10mg $150 2021-12-16 Buy
Product number Packaging Price Buy
SML3389 10MG $86.5 Buy
SML3389 50MG $350 Buy
V260000 5mg $225 Buy
CS-1679 5mg $100 Buy
CS-1679 10mg $150 Buy

Vilanterol Trifenatate Chemical Properties,Uses,Production

Chemical Properties

Vilanterol trifenatate is a white powder with a molecular weight of 774.8, and the empirical formula is C24H33Cl2NO5.C20H16O2. It insoluble in water and slightly soluble in methanol, ethanol, acetonitrile and propan-2-ol. It is slightly hygroscopic. It is provided in a micronized form.

Uses

Vilanterol Trifenatate is a long-acting β2 adrenergic receptor Agonist with alonger than 24-hour activity in humans, and is being developed to be used in combination with FF. It is also highly selective for the β2-receptor, with over 1000-fold greater selectivity compared to β1-receptors. It demonstrates prolonged bronchodilation in subjects with asthma and COPD.

Preparation

Vilanterol trifenatate is synthesized by incorporation of an oxygen atom at the homobenzylic position of the right-hand side phenyl ring of (R)-salmeterol and has suitable chemical properties for inhaled administration. The combination in fluticasone furoate (FF) and vilanterol trifenatate (VI) in a single inhaler is the first once daily combination available on the market for the treatment of stable COPD.

Definition

ChEBI: Vilanterol Trifenatate is a triphenylacetate salt obtained by combining vilanterol with one equivalent of triphenylacetic acid. Used in combination with fluticasone furoate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. It has a role as a beta-adrenergic agonist and a bronchodilator agent. It contains a vilanterol(1+).

Biological Activity

vilanterol trifenatate is a novel and selective agonist of β2-ar with a pec50 value of 10.37±0.05 [1].vilanterol trifenatate is a novel long-acting β2-ar agonist (laba) with 24h activity in development for inhaled once daily treatment. in the radioligand binding studies, vilanterol trifenatate has shown the binding affinity in the one-affinity site model with pkd values of 9.44±0.07 and 10.82±0.12 in the presence gpp(nh)p and absence gpp(nh)p, respectively. in dissociation studies, vilanterol trifenatate has been reported to bind from the β2-ar with a dissociation t1/2 value of 3.5 min in the presence of gpp(nh)p. vilanterol trifenatate has been found to have a good selectivity for β2-ar over the other β-ar receptor subtypes(β1and β3) with pec50 values of 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively. vilanterol trifenatate has exhibited at least 1000-fold selectivity over both β1-and β3-ar subtypes [1].

Dosage

The recommended and maximum dose is one inhalation of vilanterol trifenatate 25 micrograms once daily either morning or evening but at the same time every day.

Mode of action

Vilanterol Trifenatate is a selective long-acting beta2-receptor agonist (also referred to as a LABA). The pharmacologic effects of beta2-adrenoceptor agonist drugs, including vilanterol trifenatate, are at least in part attributable to stimulation of intracellular adenylate cyclase, the enzyme that catalyses the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.

References

[1] slack rj1, barrett vj, morrison vs, sturton rg, emmons aj, ford aj, knowles rg.in vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action.j pharmacol exp ther. 2013 jan; 344(1):218-30.

503068-34-6
595-91-5
503070-58-4
Synthesis of Vilanterol Trifenatate from Vilanterol and Triphenylacetic acid
Global( 197)Suppliers
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AFINE CHEMICALS LIMITED
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View Lastest Price from Vilanterol Trifenatate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vilanterol  pictures 2024-03-28 Vilanterol
503070-58-4
US $0.00 / KG 25KG 99% Inquiry PNP Biotech Co. Ltd
Vilanterol Trifenatate pictures 2024-03-26 Vilanterol Trifenatate
503070-58-4
US $10.00-100.00 / kg 1kg 99% 100 tons Wuhan Xinhao Biotechnology Co., Ltd
Vilanterol Trifenatate pictures 2024-01-02 Vilanterol Trifenatate
503070-58-4
US $70.00-700.00 / kg 10kg 0.99 20tons Zibo Hangyu Biotechnology Development Co., Ltd
  • Vilanterol  pictures
  • Vilanterol
    503070-58-4
  • US $0.00 / KG
  • 99%
  • PNP Biotech Co. Ltd

Vilanterol Trifenatate Spectrum

Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) GW 642444M GW642444M GW-642444M Vilanterol Trifenatate (API) 4-[(R)-2-[[6-[2-(2,6-Dichlorobenzyloxy)ethoxy]hexyl]amino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol triphenylacetate GW642444M; GW 642444M; GW-642444M Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-6-2-(2,6-dichlorophenyl)MethoxyethoxyhexylaMinoMethyl-4-hydroxy-1,3-benzenediMethanol (1 GW642444 (trifenatate) (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenyl 2,2,2-triphenylacetate Pharmaceuticals Chemical Vilanterol Trifenatate Powder Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1 GW642444M Trifenate (R)-4-(2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol2,2,2-triphenylacetate Vilanterol TrifenatateQ: What is Vilanterol Trifenatate Q: What is the CAS Number of Vilanterol Trifenatate Q: What is the storage condition of Vilanterol Trifenatate Q: What are the applications of Vilanterol Trifenatate Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) 503070-58-4 Benzeneacetic acid, α,α-diphenyl-, coMpd. with (α1R)-α1-[[[6-[2-[(2,6-dichlorophenyl)Methoxy]ethoxy]hexyl]aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol (1:1) vilanterol trifenatate Vilanterol Trifenate Vilanterol triphenylacetate VilanterolImpurity8Triphenylacetate 1-(3-(6-((pyridin-3-ylmethyl)amino)-1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl)ethan-1-ol 503070-58-4 C44H49Cl2NO7 C24H33Cl2NO5C20H16O2 Intermediate 503070-58-4