LEI-105 (LEI105)
- CAS No.
- 1800327-36-9
- Chemical Name:
- LEI-105 (LEI105)
- Synonyms
- LEI105;LEI-105 (LEI105);6-Phenyl-1-(6-(p-tolyl)oxazolo[4,5-b]pyridin-2-yl)hexan-1- one;1-Hexanone, 1-[6-(4-methylphenyl)oxazolo[4,5-b]pyridin-2-yl]-6-phenyl-
- CBNumber:
- CB34844982
- Molecular Formula:
- C25H24N2O2
- Molecular Weight:
- 384.47
- MDL Number:
- MOL File:
- 1800327-36-9.mol
LEI-105 (LEI105) Chemical Properties,Uses,Production
Description
LEI105 is a potent, highly selective, and reversible dual DAGL-α/DAGL-β inhibitor. Diacylglycerol lipase (DAGL)-α and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG).
Uses
LEI105 is a potent, highly selective and reversible dual diacylglycerol lipase (DAGL)-α/DAGL-β inhibitor. LEI105 reduces 2-arachidonoylglycerol levels in Neuro2A cells. LEI105 also reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. LEI105 is promising for research of diseases, such as obesity, related metabolic disorders and neuroinflammation[1].
References
[1] Baggelaar MP, et al. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. J Am Chem Soc. 2015 Jul 15;137(27):8851-7. DOI:10.1021/jacs.5b04883
LEI-105 (LEI105) Preparation Products And Raw materials
Raw materials
Preparation Products
LEI-105 (LEI105) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4993 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-024-88590548 18341751992 | 757984502@qq.com | China | 941 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29579 | 58 |
