Tyk2-IN-5
- CAS No.
- 1797432-62-2
- Chemical Name:
- Tyk2-IN-5
- Synonyms
- Tyk2-IN-5;Tyk2 inhibitor 5;Tyk2 IN 5,Tyk-2-IN-5,Tyk2IN5;Imidazo[1,2-b]pyridazine-3-carboxamide, N-[(1R,2S)-2-fluorocyclopropyl]-8-(methylamino)-6-[(2-oxo[1(2H),2'-bipyridin]-3-yl)amino]-;N-[(1R,2S)-2-fluorocyclopropyl]-8-(methylamino)-6-{[2-oxo-1-(pyridin-2-yl)pyridin-3-yl]amino}imidazo[1,2-b]pyridazine-3-carboxamide - [AC77995]
- CBNumber:
- CB35419866
- Molecular Formula:
- C21H19FN8O2
- Molecular Weight:
- 434.43
- MDL Number:
- MOL File:
- 1797432-62-2.mol
| Product description | Number | Pack Size | Price |
| Tyk2-IN-5 99.78% | CS-0090691 | 5mg | $450 |
| Tyk2-IN-5 99.78% | CS-0090691 | 10mg | $750 |
| Tyk2-IN-5 99.78% | CS-0090691 | 25mg | $1500 |
| Tyk2-IN-5 99.78% | CS-0090691 | 50mg | $2250 |
| Tyk2-IN-5 99.78% | CS-0090691 | 100mg | $3350 |
Tyk2-IN-5 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0090691 | Tyk2-IN-5 99.78% | 1797432-62-2 | 5mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0090691 | Tyk2-IN-5 99.78% | 1797432-62-2 | 10mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0090691 | Tyk2-IN-5 99.78% | 1797432-62-2 | 25mg | $1500 | 2021-12-16 | Buy |
| ChemScene | CS-0090691 | Tyk2-IN-5 99.78% | 1797432-62-2 | 50mg | $2250 | 2021-12-16 | Buy |
| ChemScene | CS-0090691 | Tyk2-IN-5 99.78% | 1797432-62-2 | 100mg | $3350 | 2021-12-16 | Buy |
Tyk2-IN-5 Chemical Properties,Uses,Production
Uses
Tyk2-IN-5 (compound 6) is a potent, selective and orally active tyrosine kinase 2 (Tyk2) inhibitor that acts on the JH2 structural domain. Tyk2-IN-5 shows a Ki value of 0.086 nM for Tyk2 JH2 and an IC50 value of 25 nM for IFNα. Tyk2-IN-5 efficiently inhibits the production of IFNγ in a pharmacodynamic rat model and is fully efficacious in a rat model of arthritis[1].
in vivo
Tyk2-IN-5 (5, 10 mg/kg; p.o.; twice daily for 20 days) shows highly efficacious in a rat adjuvant arthritis model[1].
Tyk2-IN-5 (1, 10 mg/kg; p.o.; single) inhibits IL-12/IL-18 induced IFNγ production in a dose-dependent manner[1].
Tyk2-IN-5 (10 mg/kg; p.o.; single) shows a high oral exposure and bioavailability (114%) in rat[1].
| Animal Model: | Lewis male rats (rat adjuvant arthritis model)[1]. |
| Dosage: | 5, 10 mg/kg |
| Administration: | Oral administration; twice daily for 20 days |
| Result: | Demonstrated full efficacy to prevent the rats′ paw from swelling. |
| Animal Model: | Lewis male rats (IL-12/IL-18-induced)[1]. |
| Dosage: | 1, 10 mg/kg |
| Administration: | Oral administration; single |
| Result: | Inhibited IL-12/IL-18 induced IFNγ production by 45% and 77% at doses of 1 and 10 mg/kg, respectively. |
| Animal Model: | Lewis male rats, mouse[1]. | |||||||||||||||||
| Dosage: | 10 mg/kg | |||||||||||||||||
| Administration: | Oral administration; single | |||||||||||||||||
| Result: | 1.19Pharmacokinetic Parameters of Tyk2-IN-5 in mouse and rat[1].
|
IC 50
Tyk2 JH2: 0.086 nM (Ki); IFNα: 25 nM (IC50)
References
[1] Liu C, et al. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors. ACS Med Chem Lett. 2019 Feb 21;10(3):383-388. DOI:10.1021/acsmedchemlett.9b00035
Tyk2-IN-5 Preparation Products And Raw materials
Raw materials
Preparation Products
Tyk2-IN-5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
