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E3 Ligase Ligand-Linker Conjugates 58

CAS No.
2172820-14-1
Chemical Name:
E3 Ligase Ligand-Linker Conjugates 58
Synonyms
VH032-PEG5-COOH;VH 032 amide-PEG5-acid;(S,R,S)-AHPC-PEG5-COOH;VHL Ligand-Linker Conjugates 16;E3 Ligase Ligand-Linker Conjugates 58;L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosan-1-oic acid;1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid
CBNumber:
CB36127045
Molecular Formula:
C36H54N4O11S
Molecular Weight:
750.9
MDL Number:
MFCD32693900
MOL File:
2172820-14-1.mol
Last updated:2024-07-02 08:55:06

E3 Ligase Ligand-Linker Conjugates 58 Properties

storage temp. -20°C, stored under nitrogen
solubility DMSO: ≥ 100 mg/mL (133.17 mM)
form Solid
color Colorless to off-white

E3 Ligase Ligand-Linker Conjugates 58 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 7105 VH032amide-PEG5-acid ≥95%(HPLC) 2172820-14-1 25 $199 2021-12-16 Buy
Product number Packaging Price Buy
7105 25 $199 Buy

E3 Ligase Ligand-Linker Conjugates 58 Chemical Properties,Uses,Production

Biological Activity

(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology[1].

storage

Store at -20°C

References

[1]. Chi JJ, et al. A novel strategy to block mitotic progression for targeted therapy. EBioMedicine. 2019 Oct 25. pii: S2352-3964(19)30677-2.

E3 Ligase Ligand-Linker Conjugates 58 Preparation Products And Raw materials

Raw materials

Preparation Products

E3 Ligase Ligand-Linker Conjugates 58 Suppliers

Global( 17)Suppliers
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TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32024 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1386 58
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49312 58
Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725 malulu@leyan.com China 54986 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24649 58
E3 Ligase Ligand-Linker Conjugates 58 (S,R,S)-AHPC-PEG5-COOH VH032-PEG5-COOH VHL Ligand-Linker Conjugates 16 L-Prolinamide, N-(18-carboxy-1-oxo-4,7,10,13,16-pentaoxaoctadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- VH 032 amide-PEG5-acid (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosan-1-oic acid 1-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid 2172820-14-1 C36H54N4O11S