nafiverine
- CAS No.
- 5061-22-3
- Chemical Name:
- nafiverine
- Synonyms
- DA-914;nafiverine;Nafiverina;Nafiverinum;Naftimepezine;UNII-WLT400RC9Q;EINECS 225-766-5;Bis(α-methyl-1-naphthaleneacetic acid)2,2'-(1,4-piperazinediyl)bisethyl ester;1-Naphthaleneacetic acid, α-methyl-, 1,1'-(1,4-piperazinediyldi-2,1-ethanediyl) ester;2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate
- CBNumber:
- CB3907263
- Molecular Formula:
- C34H38N2O4
- Molecular Weight:
- 538.684
- MDL Number:
- MFCD00865213
- MOL File:
- 5061-22-3.mol
| FDA UNII | WLT400RC9Q |
|---|
nafiverine Chemical Properties,Uses,Production
Originator
Naftidan,De Angeli,Italy,1969
Definition
ChEBI: Nafiverine is a member of naphthalenes.
Manufacturing Process
15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.
Therapeutic Function
Spasmolytic
nafiverine Preparation Products And Raw materials
nafiverine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | 1046@dideu.com | China | 10008 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Hebei Zhentian food additives Co., LTD | 0319-5925599 13373390591 | 13373390591@163.com | China | 11442 | 58 |