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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2458219-65-1

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: SHP2-D26;Venadaparib Impurity 92

CBNumber:: CB39823560

Molecular Formula:: C56H79ClN12O6S2

Molecular Weight:: 1115.9

MDL Number:

MOL File:: 2458219-65-1.mol

Last updated:2023-03-31 09:12:58

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INDEX NAME NOT YET ASSIGNED Properties

Boiling point	1240.1±65.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
pka	13.10±0.70(Predicted)

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Description

SHP2-D26 is a first, potent, and effective PROTAC degrader of SHP2 protein. SHP2-D26 achieves DC50 values of 6.0 and 2.6 nM in esophageal cancer KYSE520 and acute myeloid leukemia MV4;11 cells, respectively, and is capable of reducing SHP2 protein levels by >95% in cancer cells. SHP2-D26 is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4604	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1304	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	888	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 13720134139	orders@jknbiochem.com	China	5224	58
guoyungurui	18162595016	3287908757@qq.com	China	10012	58
Changsha Fuzhen Biotechnology Co.，LTD	0731-18670069958 18670069958	184792226@qq.com	China	3060	58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	17316404525	209533805@qq.com	China	9621	58

Supplier	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Jilin Province Woda Biotechnology Co., Ltd.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	58
guoyungurui	58
Changsha Fuzhen Biotechnology Co.，LTD	58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	58

SHP2-D26 Venadaparib Impurity 92 2458219-65-1 387897-99-4 C56H79ClN12O6S2