Topotecan(Tpt)
- CAS No.
- 139339-45-0
- Chemical Name:
- Topotecan(Tpt)
- Synonyms
- Ro 24-7429;Ro24-7429, 10 mM in DMSO;Tat,anti-inflammatory,antifibrotic,inhibit,Ro247429,Ro24-7429,RUNX1,Inhibitor,Apoptosis,Human immunodeficiency virus,HIV-1,anti-HIV,Ro24 7429,HIV
- CBNumber:
- CB41030572
- Molecular Formula:
- C14H13ClN4
- Molecular Weight:
- 272.73
- MDL Number:
- MFCD00909404
- MOL File:
- 139339-45-0.mol
| storage temp. | Store at -20°C |
|---|---|
| form | Solid |
| color | White to yellow |
| FDA UNII | MLW2GKK8LI |
Topotecan(Tpt) Chemical Properties,Uses,Production
Uses
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].
Definition
ChEBI: 7-chloro-N-methyl-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepin-2-amine is a benzodiazepine.
in vivo
Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2].
| Animal Model: | C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2] |
| Dosage: | 17.5 mg/kg, 35 mg/kg, and 70 mg/kg |
| Administration: | i.p.; daily; for 14 or 21 days |
| Result: | Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model. |
IC 50
HIV-1
References
[1] A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. DOI:10.1006/cimm.1996.0088
[2] Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. DOI:10.1016/j.ajpath.2021.04.006
Topotecan(Tpt) Preparation Products And Raw materials
Raw materials
Preparation Products
Topotecan(Tpt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; | sales@sun-shinechem.com | China | 1077 | 64 |
| Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 18101056239 | 3193328036@qq.com | China | 29759 | 68 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 3011 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
