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N-Desmethyl Imatinib

N-Desmethyl Imatinib structure

CAS No.: 404844-02-6

Chemical Name:: N-Desmethyl Imatinib

Synonyms: N-DesmethyL;Imatinib EP Impurity C;CGP-74588;STI 509-00;Norimatinib;no mesylate;Imatinib Imp.F;N-methylimatinib;DesMethyl IMatinib;Imatinib Impurity F

CBNumber:: CB41176575

Molecular Formula:: C28H29N7O

Molecular Weight:: 479.58

MDL Number:: MFCD07369291

MOL File:: 404844-02-6.mol

MSDS File:: SDS

Last updated:2023-09-04 16:42:00

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N-Desmethyl Imatinib Properties

Melting point	99-101°C
Density	1.268±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMF: 16 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 14 mg/ml; Ethanol: 0.20 mg/ml
form	A lyophilized solid
pka	13.28±0.70(Predicted)
FDA UNII	6GOH0N63QD

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H341-H351-H360-H362

Precautionary statements

P201-P202-P260-P263-P264-P270-P280-P301+P312-P330-P308+P313-P405-P501

Safety Statements

24/25

HS Code

29339900

NFPA 704

	0
2		0

N-Desmethyl Imatinib price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16947	N-Desmethyl Imatinib ≥95%	404844-02-6	500μg	$38	2024-03-01	Buy
Cayman Chemical	16947	N-Desmethyl Imatinib ≥95%	404844-02-6	1mg	$71	2024-03-01	Buy
Cayman Chemical	16947	N-Desmethyl Imatinib ≥95%	404844-02-6	5mg	$275	2024-03-01	Buy
Cayman Chemical	16947	N-Desmethyl Imatinib ≥95%	404844-02-6	10mg	$510	2024-03-01	Buy
TRC	D292045	N-DesmethylImatinib	404844-02-6	10mg	$490	2021-12-16	Buy

Product number	Packaging	Price	Buy
16947	500μg	$38	Buy
16947	1mg	$71	Buy
16947	5mg	$275	Buy
16947	10mg	$510	Buy
D292045	10mg	$490	Buy

N-Desmethyl Imatinib Chemical Properties,Uses,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib , an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC₅₀ = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

anti-epileptic

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

Definition

ChEBI: N-Demethylated piperazine is a member of benzamides.

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products

N-Desmethyl Imatinib Suppliers

Global( 199)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58

Supplier	Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
BOC Sciences	58

View Lastest Price from N-Desmethyl Imatinib manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-07	N-Desmethyl Imatinib USP/EP/BP 404844-02-6	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
	2019-07-06	N-Desmethyl Imatinib 404844-02-6	US $1.00 / kg	1kg	95%-99%	100kg	Career Henan Chemical Co

N-Desmethyl Imatinib USP/EP/BP
404844-02-6
US $1.10 / g
99.9%
Dideu Industries Group Limited

N-Desmethyl Imatinib
404844-02-6
US $1.00 / kg
95%-99%
Career Henan Chemical Co

N-Desmethyl Imatinib Spectrum

N-Desmethyl Imatinib(404844-02-6)¹HNMR

404844-02-6(N-Desmethyl Imatinib)Related Search:

Imatinib 1,4-Bis-[4-[4-Methyl-3-[[4-(pyridin-3-yl)pyriMidin-2-yl]aMino]phenyl]carbaMoyl]benzylpiperazine iMatinib related substance B 2-(4-METHYLPIPERAZIN-1-YLMETHYL)BENZOIC ACID Imatinib (Piperidine)-N-oxide

4-(4-Methylpiperazin-1-ylmethyl)benzoic acid Guanidine, N-(2-methyl-3-nitrophenyl)- Imatinib Impurity 7 N-DESMETHYL IMATINIB 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide

IMatinib Para-diaMinoMethylbenzene Imatinib Meta-methyl-piperazine Impurity iMatinib related substance C 3-Acetylpyridine Imatinib EP Impurity J

N-(3-GUANIDINO-4-METHYLPHENYL)-4-(METHYLPIPERAZINE-1-YL-METHYL)BENZAMIDE Imatinib EP Impurity D Imatinib (Pyridine)-N-oxide

1of4

CGP-74588 N-[4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)-benzamide Norimatinib STI 509-00 N-{4-Methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4-(piperazin-1-ylmethyl)benzamide DesMethyl IMatinib DesMethyl IMatinib-d8 iMatinib related substance A IMatinib N-DesMethyl IMpurity Imatinib Impurity F Imatinib metabolite N-Desmethyl Imatinib Imatinib impurity 6/Imatinib EP Impurity C/N-Desmethyl Imatinib/N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide Benzamide,N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-(1-piperazinylmethyl)- IMATINIB METABOLITE N-DESMETHYL IMATINIB (N-DESMETHYL IMATINIB) Imatinib EP Impurity C (N-Desmethyl Imatinib) Imatinib Imp.F Imatinib Impurity 6(Imatinib EP Impurity C) N-Desmethyl Imatinib Impurity no mesylate Imatinib Impurity 6（EP-C） Imatinib Impurity C (Imatinib (Piperazine)-N1- Oxide) (crude) Imatinib Impurity C (Imatinib (Piperidine)-N4- Oxide) Imatinib EP Impurity C (Imatinib N-Desmethyl Impurity) N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}-4... Desmethyl imatinib D4Q: What is Desmethyl imatinib D4 Q: What is the CAS Number of Desmethyl imatinib D4 Q: What is the storage condition of Desmethyl imatinib D4 Q: What are the applications of Desmethyl imatinib D4 Imatinib N-Desmethyl ImpurityQ: What is Imatinib N-Desmethyl Impurity Q: What is the CAS Number of Imatinib N-Desmethyl Impurity Q: What is the storage condition of Imatinib N-Desmethyl Impurity Q: What are the applications of Imatinib N-Desmethyl Impurity Imatinib EP Impurity C N-DesmethyL N-methylimatinib Inhibitor,N Desmethyl imatinib,v-Abl,PDGFR,inhibit,NDesmethyl imatinib,Drug Metabolite,Imatinib,N-Desmethyl imatinib,c-Kit N-Desmethyl lmatinib 404844-02-6 C28H29N7O Metabolite Reference Standard Isotopically Labeled Pharmaceutical Reference Standard Intermediates & Fine Chemicals Metabolites Pharmaceuticals Tyrosine Kinase Inhibitors Various Metabolites and Impurities