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N-Desmethyl Imatinib

N-Desmethyl Imatinib
N-Desmethyl Imatinib structure
CAS No.
404844-02-6
Chemical Name:
N-Desmethyl Imatinib
Synonyms
CGP-74588;STI 509-00;Norimatinib;N-DesmethyL;no mesylate;Imatinib Imp.F;DesMethyl IMatinib;Imatinib Impurity F;DesMethyl IMatinib-d8;Imatinib EP Impurity C
CBNumber:
CB41176575
Molecular Formula:
C28H29N7O
Formula Weight:
479.58
MOL File:
404844-02-6.mol

N-Desmethyl Imatinib Properties

Melting point:
99-101°C
Density 
1.268±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
pka
13.28±0.70(Predicted)
FDA UNII
6GOH0N63QD
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
HS Code  29339900

N-Desmethyl Imatinib price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 500μg $30 2021-12-16 Buy
Cayman Chemical 16947 N-Desmethyl Imatinib ≥95% 404844-02-6 1mg $57 2021-12-16 Buy
TRC D292045 N-DesmethylImatinib 404844-02-6 10mg $490 2021-12-16 Buy
ChemScene CS-4156 N-Desmethylimatinib 95.34% 404844-02-6 10mg $720 2021-12-16 Buy
Medical Isotopes, Inc. 8990 N-DesmethylImatinib 98% 404844-02-6 25 mg $3900 2021-12-16 Buy

N-Desmethyl Imatinib Chemical Properties,Uses,Production

Description

N-desmethyl Imatinib is a major active metabolite of imatinib (Item No. 13139), an anticancer agent that selectively targets tyrosine kinases, including Bcr-ABL, platelet-derived growth factor receptor (PDGFR), and KIT. N-desmethyl Imatinib is formed when imatinib undergoes demethylation by the cytochrome P450 (CYP) isomer CYP3A4. N-desmethyl Imatinib has the same in vitro potency at Bcr-ABL kinase as imatinib (IC50 = 38 nM for both) but is only present in plasma at 10-15% of the levels of imatinib, indicating the majority of the anticancer activity can be attributed to the parent compound.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

A metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL)

Uses

aminoglycoside antibiotic similar to gentamycin, toxic to bacterial, yeast, higher plant and mammalian cells and to protozoans and helminthes

Uses

anti-epileptic

Uses

N-Desmethyl Imatinib (Imatinib EP Impurity C) is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.

N-Desmethyl Imatinib Preparation Products And Raw materials

Raw materials

Preparation Products


N-Desmethyl Imatinib Suppliers

Global( 132)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9150 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14344 58

View Lastest Price from N-Desmethyl Imatinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-07 N-Desmethyl Imatinib USP/EP/BP
404844-02-6
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2019-07-06 N-Desmethyl Imatinib
404844-02-6
US $1.00 / kg 1kg 95%-99% 100kg Career Henan Chemical Co

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