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OICR-8268

OICR-8268 structure

CAS No.: 3000549-26-5

Chemical Name:: OICR-8268

Synonyms: OICR-8268;1H-Pyrazole-4-carboxamide, N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)-

CBNumber:: CB413731548

Molecular Formula:: C19H14Cl2F2N4O2

Molecular Weight:: 439.24

MDL Number:

MOL File:: 3000549-26-5.mol

Last updated:2025-05-19 13:47:09

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OICR-8268 Properties

Boiling point	732.640±60.00 °C(Press: 760.00 Torr)(predicted)
Density	1.493±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka	9.353±0.10(predicted)

OICR-8268 Chemical Properties,Uses,Production

Uses

OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can enable the development of DCAF1-based PROTACs[1].

IC 50

Cereblon

References

[1] Alice Shi Ming Li, et al. Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 2023 Apr 13;66(7):5041-5060. DOI:10.1021/acs.jmedchem.2c02132

OICR-8268 Preparation Products And Raw materials

Raw materials

Preparation Products

OICR-8268 Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Soochow Chirally Material Science and Technology Co.,Ltd	+86-51266834346 +86-17751128648	sales@krl-tech.com	China	942	58
Guangzhou Younan Technology Co., Ltd	020-82000279 18988968278	YN_research@163.com	China	3011	58
Chengdu PEIP Pharmaceutical Technology Co., LTD.	028-61715638 18011352545	1242335275@qq.com	China	419	58
Soochow Chirally Material Science and Technology Co.,Ltd	0512-66834346 17751187418	sales@krl-tech.com	China	1092	58

Supplier	Advantage
Soochow Chirally Material Science and Technology Co.,Ltd	58
Guangzhou Younan Technology Co., Ltd	58
Chengdu PEIP Pharmaceutical Technology Co., LTD.	58
Soochow Chirally Material Science and Technology Co.,Ltd	58

OICR-8268 1H-Pyrazole-4-carboxamide, N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)- 3000549-26-5