Isofagomine D-Tartrate
- CAS No.
- 957230-65-8
- Chemical Name:
- Isofagomine D-Tartrate
- Synonyms
- Isofagomine tartrate;Isofagomine D-Tartrate;D-Isofagomine D-Tartrate;Afegostat DTartrate,Afegostat D Tartrate;Afegostat D-Tartrate (D-Isofagomine (D-Tartrate);Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate);(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate
- CBNumber:
- CB41873108
- Molecular Formula:
- C10H19NO9
- Molecular Weight:
- 297.26
- MDL Number:
- MOL File:
- 957230-65-8.mol
| Melting point | 124-126°C |
|---|---|
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Soluble in DMSO (up to 2 mg/ml) |
| form | solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
Isofagomine D-Tartrate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16137 | Isofagomine (D-tartrate) ≥95% | 957230-65-8 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 16137 | Isofagomine (D-tartrate) ≥95% | 957230-65-8 | 5mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 16137 | Isofagomine (D-tartrate) ≥95% | 957230-65-8 | 10mg | $364 | 2024-03-01 | Buy |
| Usbiological | 293800 | Isofagomine D-tartrate | 957230-65-8 | 5mg | $460 | 2021-12-16 | Buy |
| TRC | I816010 | IsofagomineD-Tartrate | 957230-65-8 | 5mg | $180 | 2021-12-16 | Buy |
Isofagomine D-Tartrate Chemical Properties,Uses,Production
Description
Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50?= 0.06 μM.1?Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2?Displays a direct pharmacological chaperone effect greatly increasing the amount of newly synthesized GlcCerase that traffics out of the ER.2
Chemical Properties
Isofagomine D-Tartrate is Off-White Solid
Uses
Isofagomine D-Tartrate is used as human acid ?glucosidase inhibitor and for the treatment of Gaucher disease
Uses
Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.
References
1) Kuriyama?et al.?(2008),?In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culture; Bioorg. Med. Chem.,?16?7330 2) Steet?et al. (2006),?The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms; Proc. Natl. Acad. Sci. USA,?103?13813
Isofagomine D-Tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16687 | 50 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |