8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)-
![8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- Structure](CAS/GIF/155798-07-5.gif)
- CAS No.
- 155798-07-5
- Chemical Name:
- 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)-
- Synonyms
- IOFLUPANE;Ioflupane 123I;ioflupane I(123)
- CBNumber:
- CB42448673
- Molecular Formula:
- C18H23FINO2
- Molecular Weight:
- 431.283
- MDL Number:
- MFCD08061453
- MOL File:
- 155798-07-5.mol
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- Properties
| Melting point | 82-83° |
|---|---|
| alpha | D24 -12.8° |
| FDA UNII | 3MM99T8R5Q |
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- Chemical Properties,Uses,Production
Description
loflupane was launched as a new imaging agent for investigation of the dopaminergic neurons and the early diagnosis of Parkinson’s disease and related syndromes. This (123I) iodine-labeled agent was developed for imaging with single-photon emission computed tomography (SPECT); it binds to dopamine transporters on cerebral neurons, enabling the detection of an eventual loss of functional neurons, particularly in the striatal region. The use in clinical routine of SPECT technique with this new agent generates reliable and reproducible results in healthy control subjects as well as in patients with Parkinson’s disease. So, it displays a quantification of striatal dopaminergic function and can help in the identification of the parkinsonian syndromes and their differentiation from syndromes due to other diseases. The major metabolic reactions in healthy humans are hydrolysis of the ester bond to the free acid and N-dealkylation to the 123-I labeled noranalog.
Originator
Research Biochemicals Int (UK)
Definition
ChEBI: An azabicycloalkane that is ecgonine methyl ester in which the N-methyl group is replaced by 3-fluoropropyl and the 3beta-hydroxy group is replaced by 4-(123I)iodophenyl. Used for the imaging of dopa ine transporters in the brain of adult patients with potential Parkinsonian Syndromes.
brand name
DatSCAN
8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- Preparation Products And Raw materials
Raw materials
Preparation Products
155798-07-5(8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)-)Related Search:
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