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ChemicalBook >> CAS DataBase List >>(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Structure
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide structure
CAS No.
300353-13-3
Chemical Name:
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
Synonyms
Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
CBNumber:
CB42516200
Molecular Formula:
C18H22N2O3S2
Molecular Weight:
378.51
MDL Number:
MOL File:
300353-13-3.mol
MSDS File:
SDS
Last updated:2023-07-12 17:16:27
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(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Properties

Density 1.306
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)
form Powder
pka 8.65±0.50(Predicted)

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Axon Medchem Axon1356 RO28-1675-RO28-0450,(R)- 99% 300353-13-3 2mg $115.5 2021-12-16 Buy
Axon Medchem Axon1356 RO28-1675-RO28-0450,(R)- 99% 300353-13-3 5mg $159.5 2021-12-16 Buy
ChemScene CS-2016 RO-28-1675 99.95% 300353-13-3 5mg $258 2021-12-16 Buy
American Custom Chemicals Corporation API0004737 (R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE 95.00% 300353-13-3 2MG $262 2021-12-16 Buy
ChemScene CS-2016 RO-28-1675 99.95% 300353-13-3 10mg $444 2021-12-16 Buy
Product number Packaging Price Buy
Axon1356 2mg $115.5 Buy
Axon1356 5mg $159.5 Buy
CS-2016 5mg $258 Buy
API0004737 2MG $262 Buy
CS-2016 10mg $444 Buy

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Uses,Production

Definition

ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.

Biological Activity

RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.

in vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).

in vivo

RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.

Animal Model: 10 weeks old male C57BL/6J mice
Dosage: 50 mg/kg
Administration: Oral administration
Result: Reduced blood glucose levels.
Animal Model: C57BL/6J mice
Dosage: 10 mg/kg
Administration: Oral administr ation
Result: AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered.

target

EC50: 54 nM (glucokinase)

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials

Raw materials

Preparation Products

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers

Global( 44)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6009 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
SPIRO PHARMA eric_feng1954@126.com China 9254 55
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9708 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
SPIRO PHARMA 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Ro 0281675 BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)- Ro 28-1675 RO 028-1675;RO 0281675 RO 28-1675 - RO 28-0450, (R)- RO281675,RO 28 1675 RO 28-1675 (Ro 0281675) 300353-13-3