GLYX 13
- CAS No.
- 117928-94-6
- Chemical Name:
- GLYX 13
- Synonyms
- GLYX 13;GIYX-13;CS-1640;Rapastinel;TPPT-amide;GLYX 13 TFA;UNII-6A1X56B95E;NRX-1074 GLYX-13;GLYX13(Rapastinel);Rapastinel(GLYX-13)
- CBNumber:
- CB42518800
- Molecular Formula:
- C18H31N5O6
- Molecular Weight:
- 413.47
- MDL Number:
- MFCD12912477
- MOL File:
- 117928-94-6.mol
- MSDS File:
- SDS
Boiling point | 844.2±65.0 °C(Predicted) |
---|---|
Density | 1.370±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMF: 25 mg/ml; DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml |
pka | 12.26±0.45(Predicted) |
form | powder |
color | white to tan |
Water Solubility | Soluble to 2 mg/ml in water |
FDA UNII | 6A1X56B95E |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
GLYX 13 price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0109 | GLYX-13 trifluoroacetate ≥98% (HPLC) | 117928-94-6 | 1mg | $214 | 2024-03-01 | Buy |
Cayman Chemical | 21385 | GLYX 13 ≥98% | 117928-94-6 | 1mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 21385 | GLYX 13 ≥98% | 117928-94-6 | 5mg | $426 | 2024-03-01 | Buy |
Tocris | 3406 | GLYX13 | 117928-94-6 | 1 | $150 | 2021-12-16 | Buy |
TRC | G650020 | GLYX-13 | 117928-94-6 | 1mg | $60 | 2021-12-16 | Buy |
GLYX 13 Chemical Properties,Uses,Production
Uses
GLYX-13 is a long lasting and rapid acting antidepressant. Investigational drug for the treatment of depressive disoder.
Uses
Rapastinel is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Uses
GLYX-13 trifluoroacetate has been used as an activator of NMDA (N-methyl-D-aspartate) receptor.
Biochem/physiol Actions
GLYX-13 is a glycine-site functional partial agonist (GFPA) selective modulator of the NMDA receptor (NMDAR). It is a brain penetrable tetrapeptide which acts as a positive allosteric modulator of the NMDA receptor, acting via the glycine site. GLYX-13 has been found to be a cognitive enhancer in learning models and is currently in clinical trials as an antidepressant.
storage
Store at -20°C
GLYX 13 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1143 | 58 |
Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 269 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9357 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2534 | 58 |
View Lastest Price from GLYX 13 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | GLYX-13
117928-94-6
|
US $30.00 / box | 1box | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-18 | GLYX 13
117928-94-6
|
US $0.00 / g | 1g | 99% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-30 | Rapastinel
117928-94-6
|
US $240.00 / g | 1g/Bag | 98% | 10KG | Baoji Guokang Bio-Technology Co., Ltd. |
- GLYX-13
117928-94-6
- US $30.00 / box
- 98%
- hebei hongtan Biotechnology Co., Ltd
- GLYX 13
117928-94-6
- US $0.00 / g
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Rapastinel
117928-94-6
- US $240.00 / g
- 98%
- Baoji Guokang Bio-Technology Co., Ltd.