2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
![2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Structure](CAS/GIF/864289-85-0.gif)
- CAS No.
- 864289-85-0
- Chemical Name:
- 2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- Synonyms
- C-021;CCR4 Antagonist;C 021 dihydrochloride;C-021 (CCR4 antagonist);4'-?bipiperidin]?-?1'-?yl-?N-?cycloheptyl-?6;2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine;4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine;2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride
- CBNumber:
- CB42518956
- Molecular Formula:
- C27H41N5O2.2HCl
- Molecular Weight:
- 541
- MDL Number:
- MFCD16618393
- MOL File:
- 864289-85-0.mol
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21885 | CCR4 Antagonist ≥98% | 864289-85-0 | 1mg | $46 | 2021-12-16 | Buy |
| Cayman Chemical | 21885 | CCR4 Antagonist ≥98% | 864289-85-0 | 5mg | $150 | 2021-12-16 | Buy |
| Tocris | 3581 | C021dihydrochloride ≥99%(HPLC) | 864289-85-0 | 10 | $229 | 2021-12-16 | Buy |
| Tocris | 3581 | C021dihydrochloride ≥99%(HPLC) | 864289-85-0 | 50 | $961 | 2021-12-16 | Buy |
| Usbiological | 254845 | C 021 dihydrochloride | 864289-85-0 | 10mg | $480 | 2021-12-16 | Buy |
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Chemical Properties,Uses,Production
Biological Activity
c 021 dihydrochloride is a potent antagonist of ccr4 with ic50 values of 0.039 and 0.14 μm for inhibition of chemotaxis in mouse and human, respectively [1].cc chemokine receptor 4 (ccr4) is a g protein-coupled receptor and is a receptor for the cc chemokines, which play an important role in the development and function of the immune system.c 021 dihydrochloride is a potent ccr4 antagonist. c 021 dihydrochloride potently inhibited functional chemotaxis in mice and human with ic50 values of 0.039 and 0.14 μm, respectively. in the gtpγs-binding assay, c 021 dihydrochloride was active with ic50 value of 0.018 μm [1].treatment mice with azoxymethane (aom), which induced hepatic encephalopathy, aom significantly increased microglia activation and the concentrations of ccl2 in the liver, serum, and cortex. c 021 dihydrochloride reduced liver damage and significantly improved the neurological outcomes. also, c 021 dihydrochloride reduced microglia activation and phosphorylation of erk1/2, and inhibited aom-induced cytokine upregulation [2].
References
[1]. yokoyama k, ishikawa n, igarashi s, et al. potent and orally bioavailable ccr4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. bioorg med chem, 2009, 17(1): 64-73.
[2]. mcmillin m, frampton g, thompson m, et al. neuronal ccl2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. j neuroinflammation, 2014, 11: 121.
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-[1,4'-Bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinaminedihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3444 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Baonuo Technology (Beijing) Co., Ltd. | 010-80768195 | China | 78 | 58 | |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 | 3362556465@qq.com | China | 8000 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 61720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6712 | 58 |