Chaetominine
- CAS No.
- 918659-56-0
- Chemical Name:
- Chaetominine
- Synonyms
- CS-493;NSC746369;NSC 746369;NSC-746369;Chaetominine;(–)-Chaetominine;(-)-CHAETOMININE;Chaetominine (-)-Chaetominine;(2S,2a1S,4R,5AS)-5a-hydroxy-2-methyl-4-(4-oxoquinazolin-3(4H)-yl)-2a1,4,5,5a-tetrahydro-1H-2a;(2S,4R,5aS,9cS)-4,5,5a,9c-Tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione
- CBNumber:
- CB42521091
- Molecular Formula:
- C22H18N4O4
- Molecular Weight:
- 402.4
- MDL Number:
- MFCD22380597
- MOL File:
- 918659-56-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H317 | |||||||||
| Precautionary statements | P261-P264-P272-P280-P302+P352-P305+P351+P338-P333+P313-P321-P337+P313-P363-P501 | |||||||||
| NFPA 704 |
|
Chaetominine price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13135 | (–)-Chaetominine ≥95% | 918659-56-0 | 500μg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 13135 | (–)-Chaetominine ≥95% | 918659-56-0 | 2.5mg | $639 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | PXT0001712 | CHAETOMININE 95.00% | 918659-56-0 | 5MG | $498.88 | 2021-12-16 | Buy |
| AK Scientific | X5706 | Chaetominine | 918659-56-0 | 2.5mg | $1005 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PXT0001712 | CHAETOMININE 95.00% | 918659-56-0 | 250MG | $1867.95 | 2021-12-16 | Buy |
Chaetominine Chemical Properties,Uses,Production
Description
(–)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (–)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.
Definition
ChEBI: Chaetominine is an organic heterotetracyclic compound that consists of 4,5,5a,9c-tetrahydro-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione substituted by a hydroxy group at position 5, a methyl group at position 2 and a 4-oxoquinazolin-3(4H)-yl group at position 4 (the 2S,4R,5aS,9cS stereoisomer). It is a cytotoxic alkaloid isolated from the endophytic fungus Chaetomium. It has a role as a metabolite. It is an organic heterotetracyclic compound, a member of quinazolines, a lactam and an indole alkaloid.
Chaetominine Preparation Products And Raw materials
Raw materials
Preparation Products
Chaetominine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Xunteng International Trading Co.,Limited | China Hong Kong | 878 | 55 | ||
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28821 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3574 | 58 |
| Cckinase, Inc. | +1 (732)236-3202 | sales@cckinase.com | United States | 2738 | 58 |