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25-hydroxy Cholesterol-d6

CAS No.
88247-69-2
Chemical Name:
25-hydroxy Cholesterol-d6
Synonyms
25-hydroxy Cholesterol-d6;cholest-5-ene-3,25-diol-d6;cholest-5-ene-3β,25-diol-d6;CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6;(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CBNumber:
CB42589994
Molecular Formula:
C27H40D6O2
Molecular Weight:
408.689910668
MDL Number:
MOL File:
88247-69-2.mol
Last updated:2023-06-08 09:01:59

25-hydroxy Cholesterol-d6 Properties

Melting point >155°C (dec.)
storage temp. -20°C
solubility Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated
form Solid
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
NFPA 704
0
3 0

25-hydroxy Cholesterol-d6 price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11099 25-hydroxy Cholesterol-d6 ≥99% deuterated forms (d1-d6) 88247-69-2 500μg $63 2024-03-01 Buy
Cayman Chemical 11099 25-hydroxy Cholesterol-d6 ≥99% deuterated forms (d1-d6) 88247-69-2 1mg $117 2024-03-01 Buy
Cayman Chemical 11099 25-hydroxy Cholesterol-d6 ≥99% deuterated forms (d1-d6) 88247-69-2 5mg $486 2024-03-01 Buy
Usbiological 160140 25-Hydroxy Cholesterol-d6 88247-69-2 1mg $460 2021-12-16 Buy
TRC H918032 25-HydroxyCholesterol-d6 88247-69-2 10mg $1190 2021-12-16 Buy
Product number Packaging Price Buy
11099 500μg $63 Buy
11099 1mg $117 Buy
11099 5mg $486 Buy
160140 1mg $460 Buy
H918032 10mg $1190 Buy

25-hydroxy Cholesterol-d6 Chemical Properties,Uses,Production

Uses

25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.

General Description

25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.

Biochem/physiol Actions

25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase. It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.

25-hydroxy Cholesterol-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

25-hydroxy Cholesterol-d6 Suppliers

Global( 38)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Shandong Xiya Chemical Co., Ltd 4009903999 13355009207 3007715519@qq.com China 18738 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25009 65
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9685 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Codow Chemical Co.,Ltd. 18620099427 amy@howeipharm.com China 17698 55
Chemaphor Chemical Services. (613) 656-7272 l.elliott@chemaphor.com Canada 22 58
Chengdu Dianchun Technology Co., Ltd 400-1166-196 18502815961 cdhxsj@163.com China 14623 60
Nanjing Haolv Biotechnology Co.,Ltd 025-84622273 17361806303 3004208264@qq.com China 3022 58
25-hydroxy Cholesterol-d6 cholest-5-ene-3,25-diol-d6 CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6 (3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol cholest-5-ene-3β,25-diol-d6 88247-69-2 C27H40D6O2