3,5-dimethyl PIT-1
- CAS No.
- 701947-53-7
- Chemical Name:
- 3,5-dimethyl PIT-1
- Synonyms
- DM-PIT-1;3,5-dimethyl PIT-1;DM-PIT-1 (3,5-dimethyl PIT-1);3,5 dimethyl PIT 1,3,5dimethyl PIT1;PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem;N-[(2-hydroxy-5-nitrophenyl)carbamothioyl]-3,5-dimethylbenzamide;Benzamide, N-[[(2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-3,5-dimethyl-
- CBNumber:
- CB42590015
- Molecular Formula:
- C16H15N3O4S
- Molecular Weight:
- 345.37
- MDL Number:
- MOL File:
- 701947-53-7.mol
- MSDS File:
- SDS
3,5-dimethyl PIT-1 price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 524619 | PIP3 Antagonist II, DM-PIT-1 - CAS 701947-53-7 - Calbiochem The PIP3 Antagonist II, DM-PIT-1, also referenced under CAS 701947-53-7, controls the biological activity of PIP3. |
701947-53-7 | 25mg | $251 | 2024-03-01 | Buy |
Cayman Chemical | 10727 | 3,5-dimethyl PIT-1 ≥98% | 701947-53-7 | 1mg | $26 | 2024-03-01 | Buy |
Cayman Chemical | 10727 | 3,5-dimethyl PIT-1 ≥98% | 701947-53-7 | 5mg | $111 | 2024-03-01 | Buy |
Cayman Chemical | 10727 | 3,5-dimethyl PIT-1 ≥98% | 701947-53-7 | 10mg | $195 | 2024-03-01 | Buy |
Cayman Chemical | 10727 | 3,5-dimethyl PIT-1 ≥98% | 701947-53-7 | 25mg | $426 | 2024-03-01 | Buy |
3,5-dimethyl PIT-1 Chemical Properties,Uses,Production
Description
PtdIns-
General Description
A cell-permeable benzoylthiourea compound that is shown to compete against PIP3 (Cat. No. 524615) for binding PH domains of Akt1 (IC50 ≥31 μM), ARNO, GRP1, and PKD1. Effectively blocks PIP3-dependent cellular PI3K-PDK1-Akt signaling pathway activation in U87MG (25 to 100 μM for 3 d) and PDGF-induced Akt and GRP membrane translocation in serum-starved SUM159 cells (1 h 100 μM pretreatment), while being inactive against PDGF-induced Btk translocation or PMA-induced PLC-δ and TAPP1/2 translocations. Although DM-PIT-1 can be administered as a DMSO stock for effective culture treatments, incorporating DM-PIT-1 into PEG-PE mixed micelles enhances its solubility (up to 1 mM) and i.v. dosing limit for more effective in vivo administrations (5% vs. 41% of control 4T1 tumor size in mice via 1 mg/kg micelles-formulated or 0.4 mg/kg free drug daily i.v., respectively).
3,5-dimethyl PIT-1 Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-dimethyl PIT-1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23980 | 58 |
Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7979 | 58 |