LEE011
- CAS No.
- 1256963-02-6
- Chemical Name:
- LEE011
- Synonyms
- Rebosini;Ribociclib(LEE011);4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine;CS-842;LEE011;CDK4-IN-1;CDK4 inhibitor;CDK4/6 inhibitor;LEE011 USP/EP/BP;Ribociclib Free Base
- CBNumber:
- CB42655411
- Molecular Formula:
- C22H29ClN8
- Molecular Weight:
- 440.97
- MDL Number:
- MFCD25976762
- MOL File:
- 1256963-02-6.mol
- MSDS File:
- SDS
Melting point | >180°C (dec.) |
---|---|
Boiling point | 679.3±65.0 °C(Predicted) |
Density | 1.31±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 7.57±0.50(Predicted) |
form | Solid |
color | Beige |
FDA UNII | TK8ERE8P56 |
LEE011 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | C228130 | CDK4/6Inhibitor | 1256963-02-6 | 25mg | $1470 | 2021-12-16 | Buy |
Matrix Scientific | 153615 | 4-(5-Chloro-3-isopropyl-1H-pyrazol-4-yl)-N-(5-(4-(dimethylamino)piperidin-1-yl)pyridin-2-yl)pyrimidin-2-amine 95% | 1256963-02-6 | 1g | $1656 | 2021-12-16 | Buy |
Biorbyt Ltd | orb181278 | Ribociclib (LEE011) >99% | 1256963-02-6 | 1g | $1802 | 2021-12-16 | Buy |
Biorbyt Ltd | orb546255 | Ribociclib >98% | 1256963-02-6 | 10mg | $190.4 | 2021-12-16 | Buy |
Biorbyt Ltd | orb546255 | Ribociclib >98% | 1256963-02-6 | 50mg | $430.1 | 2021-12-16 | Buy |
LEE011 Chemical Properties,Uses,Production
Description
LEE011 (also known as ribociclib) is a CDK4/6 inhibitor. It has been recently approved by FDA (brand name: Kisqali®) to be combined with an aromatase inhibitor for initial endocrine-based therapy for treatment of postmenopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) advanced or metastatic breast cancer. It inhibits the growth of tumor cells by arresting the cells at the G1 checkpoint, which prevents the tumor cells from proliferating. In the phase III trial, it demonstrating statistically significant improvement in progression-free survival (PFS) compared to letrozole alone at the first pre-planned interim analysis.
References
S. Kim et al. "Abstract PR02: LEE011: An orally bioavailable, selective small molecule inhibitor of CDK4/6- Reactivating Rb in cancer." Molecular Cancer Therapeutics 12.11_Supplement (2013):PR02-PR02.
Bardia, Aditya, et al. "Phase Ib/II study of LEE011, everolimus, and exemestane in postmenopausal women with ER+/HER2-metastatic breast cancer." Asco 2014.
https://www.novartis.com/news/media-releases/novartis-kisqalir-ribociclib-lee011-receives-fda-approval-first-line-treatment
Uses
CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer.
LEE011 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9328 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Echemi Group | 86-18905328650 18905328650 | pharma@echemi.com | CHINA | 215 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from LEE011 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-12 | Ribociclib
1256963-02-6
|
US $0.00 / g | 1g | 98% HPLC | 1kg | shandong perfect biotechnology co.ltd | ||
2023-07-31 | LEE011/ Ribociclib
1256963-02-6
|
US $10.00-20.00 / kg | 1kg | 99% | 20tons | Hebei Linwo New Material Technology Co., LTD | ||
2021-07-02 | LEE011 USP/EP/BP
1256963-02-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
- Ribociclib
1256963-02-6
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
- LEE011/ Ribociclib
1256963-02-6
- US $10.00-20.00 / kg
- 99%
- Hebei Linwo New Material Technology Co., LTD
- LEE011 USP/EP/BP
1256963-02-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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