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EW-7197

EW-7197
EW-7197
CAS No.
1352608-82-2
Chemical Name:
EW-7197
Synonyms
TEW-7197;NOV-1301;CPD3325-A5;Vactosertib;N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole;N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine;N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline;1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
CBNumber:
CB42729651
Molecular Formula:
C22H18FN7
Formula Weight:
399.43
MOL File:
1352608-82-2.mol

EW-7197 Properties

SAFETY

EW-7197 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19231 EW-7197 ≥98% 1352608-82-2 1mg $99 2018-11-13 Buy
Cayman Chemical 19231 EW-7197 ≥98% 1352608-82-2 5mg $188 2018-11-13 Buy
Cayman Chemical 19231 EW-7197 ≥98% 1352608-82-2 10mg $297 2018-11-13 Buy

EW-7197 Chemical Properties,Uses,Production

Description

EW-7197 is a novel ALK-5 kinase inhibitor as well as TGF-β Type I Receptor Kinase Inhibitor. Study has shown that it can potently inhibit the breast to lung metastasis. Mice study has demonstrated that EW-7197 inhibited Smad/TGFβ signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice. EW-7197 also inhibited the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice. Furthermore, EW-7197 enhanced cytotoxic T lymphocyte activity in 4T1 orthotopic-grafted mice and increased the survival time of 4T1-Luc and 4T1 breast tumor-bearing mice. It can also inhibit hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling. Therefore, it is a potential antitumor reagent. 

References

Park, S. A., et al. "EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling." Cellular & Molecular Life Sciences 72.10(2015):2023-2039.
Kim, Min Jin, et al. "TGF-β Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1α-Induced Epithelial Mesenchymal Transition." Cellular Physiology & Biochemistry International Journal of Experimental Cellular Physiology Biochemistry & Pharmacology 38.2(2016):571.
Son, J. Y., et al. "EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis." Molecular Cancer Therapeutics13.7(2014):1704.

EW-7197 Preparation Products And Raw materials

Raw materials

Preparation Products


EW-7197 Suppliers

Global( 45)Suppliers
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Chengdu Henghui Pharm Tec Co. Ltd.
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ATK CHEMICAL COMPANY LIMITED
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Shanghai Boyle Chemical Co., Ltd.
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BOC Sciences
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Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7567 61
MedChemexpress LLC 609-228-6898
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AdooQ BioScience, LLC +1 (866) 930-6790
+1 (866) 333-9607 info@adooq.com United States 2777 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 021-64556180
021-69018966*808 sales-cpd@caerulumpharma.com China 511 58
Wuhan Biocar Bio-Pharm Co., Ltd. 13343428090
86-027-87050469 sales@biocar.cn China 1726 50
Shanghai XR Chemical Technology Co., Ltd. 021-31007982 18019432809
021-31007982 info@xrpharma.com QQ:2723856851 3521982057 China 821 55

1352608-82-2(EW-7197)Related Search:


  • N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine
  • NOV-1301
  • TEW-7197
  • N-[[4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]methyl]-2-fluoroaniline
  • CPD3325-A5
  • N-(2-Fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo-[1,5-a]pyridin-6-yl-1H-imidazole
  • 1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-
  • Vactosertib
  • C22H18FN7
  • Inhibitors
  • 1352608-82-2
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