5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE
- CAS No.
- 47208-82-2
- Chemical Name:
- 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE
- Synonyms
- PFKFB4 inhibitor 5MPN;5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE;1-Pentanol, 5-[(8-methoxy-4-quinolinyl)amino]-, 1-nitrate
- CBNumber:
- CB42753375
- Molecular Formula:
- C15H19N3O4
- Molecular Weight:
- 305.33
- MDL Number:
- MFCD00089445
- MOL File:
- 47208-82-2.mol
| Product description | Number | Pack Size | Price |
| 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE AldrichCPR | S656801 | 1 unit | $216 |
| 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Aldrich | S656801 | 250mg | $209 |
| 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE 95.00% | CHM0310080 | 5MG | $499.16 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H318-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501-P280-P305+P351+P338-P310 |
5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S656801 | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE AldrichCPR | 47208-82-2 | 1 unit | $216 | 2025-07-31 | Buy |
| Sigma-Aldrich | S656801 | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Aldrich | 47208-82-2 | 250mg | $209 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CHM0310080 | 5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE 95.00% | 47208-82-2 | 5MG | $499.16 | 2021-12-16 | Buy |
5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Chemical Properties,Uses,Production
Uses
5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines[1].
in vivo
5MPN (120 mg/kg; p.o.) suppresses the growth of Lewis lung carcinomas (LLC) grown in syngeneic mice and H460 human lung adenocarcinoma xenografts grown in athymic mice without affecting body weight[1].
5MPN causes a reduction in Ki67-positive cells in the LLC xenografts suggesting that 5MPN may be reducing cell cycle progression in vivo[1].
| Animal Model: | C57BL/6 mice[1] |
| Dosage: | 120 mg/kg |
| Administration: | P.o. |
| Result: | Suppressed the growth of Lewis lung carcinomas (LLC) grown in syngeneic mice and H460 human lung adenocarcinoma xenografts grown in athymic mice without affecting body weight. |
References
[1] Chesney J, et al. Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor. Oncotarget. 2015;6(20):18001-18011. DOI:10.18632/oncotarget.4534
5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Preparation Products And Raw materials
Raw materials
Preparation Products
5-(N-(8-METHOXY-4-QUINOLYL)AMINO)PENTYL NITRATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4757 | 55 | |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| https://hanhongsci.com/ | 021-54306202 18917919676 | info@hanhongsci.com | China | 29995 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Afflon Pharmaceutical (Sichuan) Co., Ltd. | 17336178085 | 1684779048@qq.com | China | 1728 | 58 |
| Guangzhou Hanke Technology Co., Ltd. | 18922111618 | CHINA | 91 | 58 |
