ALS-8176
- CAS No.
- 1445385-02-3
- Chemical Name:
- ALS-8176
- Synonyms
- ALS-8176;ALS-008176;Lumicitabine;Lumicitabine (ALS-8176);ALS-8176 (Lumicitabine;LUMICITABINE;ALS8176;ALS 8176;4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine;Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate);4-Amino-1-{5-chloro-2,5-dideoxy-2-fluoro-3-O-isobutyryl-4-[(isobutyryloxy)methyl]-a-L-lyxofuranosyl}-2(1H)-pyrimidinone
- CBNumber:
- CB43133345
- Molecular Formula:
- C18H25ClFN3O6
- Molecular Weight:
- 433.86
- MDL Number:
- MOL File:
- 1445385-02-3.mol
| Product description | Number | Pack Size | Price |
| Lumicitabine 99.78% | CS-5699 | 1mg | $180 |
| Lumicitabine 99.78% | CS-5699 | 5mg | $420 |
| Lumicitabine 99.78% | CS-5699 | 10mg | $600 |
| Lumicitabine 99.78% | CS-5699 | 50mg | $1800 |
| ALS-8176 | orb611588 | 250mg | $2395.3 |
| Boiling point | 533.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 50 mg/mL (115.24 mM) |
| form | Solid |
| pka | 4.26±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | BNW5PQ52G1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360 |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
ALS-8176 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5699 | Lumicitabine 99.78% | 1445385-02-3 | 1mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-5699 | Lumicitabine 99.78% | 1445385-02-3 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-5699 | Lumicitabine 99.78% | 1445385-02-3 | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-5699 | Lumicitabine 99.78% | 1445385-02-3 | 50mg | $1800 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611588 | ALS-8176 | 1445385-02-3 | 250mg | $2395.3 | 2021-12-16 | Buy |
ALS-8176 Chemical Properties,Uses,Production
Uses
Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase.
in vivo
Lumicitabine demonstrates excellent anti-RSV efficacy and safety in a phase 2 clinical RSV challenge study. It exhibits good oral bioavailability and a high level of 2c-TP in vivo. Lumicitabine has excellent stability profiles in formulations (>24 h storage stability in 0.5% methylcellulose aqueous formulation at rt) and simulats gastric and intestinal fluids (half-life >2 h). Its solubility is adequate to support oral administration in solutions with relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following oral administration of Lumicitabine to monkeys[2]. In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1].
References
[1] DeVincenzo JP, et al. Activity of Oral ALS-008176 in a Respiratory Syncytial Virus Challenge Study. N Engl J Med. 2015 Nov 19;373(21):2048-58. DOI:10.1056/NEJMoa1413275
[2] Wang G, et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J Med Chem. 2015 Feb 26;58(4):1862-78. DOI:10.1021/jm5017279
ALS-8176 Preparation Products And Raw materials
Raw materials
Preparation Products
ALS-8176 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9985 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Jiangxi Huihe Chemical Co., Ltd. | +86-19189228086 +8618858568638 | wuzhouding@huihecrop.com | China | 886 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
View Lastest Price from ALS-8176 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-21 | Lumicitabine
1445385-02-3
|
US $347.00-541.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Lumicitabine
1445385-02-3
- US $347.00-541.00 / mg
- TargetMol Chemicals Inc.
