5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride
- CAS No.
- 76350-04-4
- Chemical Name:
- 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride
- Synonyms
- Iopromide P-1;5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride;3- methoxy acetamide -5- (2,3- dihydroxyl procarbamide) -2,4,6- triiodobenzoyl chloride;Benzoyl chloride, 3-[[(2,3-dihydroxypropyl)amino]carbonyl]-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-
- CBNumber:
- CB43169614
- Molecular Formula:
- C14H14ClI3N2O6
- Molecular Weight:
- 722.44
- MDL Number:
- MOL File:
- 76350-04-4.mol
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride Chemical Properties,Uses,Production
Uses
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride is an important intermediate for the synthesis of Iopromide, which is an iodinated contrast medium for X-ray imaging. It is also an important organic reagent for the synthesis of many organic compounds.
Preparation
N-[3,5-Bis(chlorocarbonyl)-2,4,6-triiodophenyl]amine (100g, 0.17mol) ) was added with 100ml of DMA to dissolve, and methoxyacetyl chloride (27.3g, 0.25mol) was added dropwise at 20°C for about 1 hour. The reaction was kept at 20-30°C for 5-8 hours. Cool the mixture to 5°C, water, potassium carbonate (58.7 g, 0.42 mol), 400 ml of dichloromethane, and 3-amino-1,2-propanediol (17.8 g, 0.2 mol) were added dropwise. After 8 hours, 400 ml of cold water was quickly added to the reaction solution. After crystallization, filtered, washed with a small amount of water, and dried to obtain 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride.
5-methoxyacetylamino-2,4,6-triiodoisophthalic acid (2,3-dihydroxypropyl)amide chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Gansu Songsheng Pharmaceutical Co. , Ltd. | 13705130158 | sales@unitechemical.com | China | 145 | 58 |