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BML-190

BML-190 structure

CAS No.: 2854-32-2

Chemical Name:: BML-190

Synonyms: IMMA;BML-190;BML-190 USP/EP/BP;BML-190;BML 190;BML190;Indomethacin morpholinamide;INDOMETHACIN MORPHOLINYLAMIDE;BML-190 (Indomethacin morpholinylamide;Indomethacin Morpholinylamide Impurity;BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE;N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine

CBNumber:: CB4328320

Molecular Formula:: C23H23ClN2O4

Molecular Weight:: 426.89

MDL Number:: MFCD01317813

MOL File:: 2854-32-2.mol

Last updated:2023-05-18 11:31:00

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BML-190 Properties

Melting point	162.0-163.5 °C
Boiling point	586.7±50.0 °C(Predicted)
Density	1.31
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: >20mg/mL
form	solid
pka	-0.97±0.20(Predicted)
color	off-white

SAFETY

Risk and Safety Statements

WGK Germany	3
Toxicity	rat,LDLo,oral,40mg/kg (40mg/kg),Bollettino Chimico Farmaceutico. Vol. 114, Pg. 309, 1975.

BML-190 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	70275	IMMA ≥98%	2854-32-2	5mg	$26	2024-03-01	Buy
Cayman Chemical	70275	IMMA ≥98%	2854-32-2	10mg	$48	2024-03-01	Buy
Cayman Chemical	70275	IMMA ≥98%	2854-32-2	50mg	$195	2024-03-01	Buy
Cayman Chemical	70275	IMMA ≥98%	2854-32-2	100mg	$341	2024-03-01	Buy
Usbiological	254783	BML-190	2854-32-2	10mg	$353	2021-12-16	Buy

Product number	Packaging	Price	Buy
70275	5mg	$26	Buy
70275	10mg	$48	Buy
70275	50mg	$195	Buy
70275	100mg	$341	Buy
254783	10mg	$353	Buy

BML-190 Chemical Properties,Uses,Production

Uses

BML-190, is a selective cannabinoid CB2 receptor, and it is also used for treatment of organophosphate and carbamate toxicity.

Definition

ChEBI: 2-[1-[(4-chlorophenyl)-oxomethyl]-5-methoxy-2-methyl-3-indolyl]-1-(4-morpholinyl)ethanone is a N-acylindole.

Biological Activity

Potent and selective CB 2 receptor ligand (K i values are 435 nM and > 2 μ M for CB 2 and CB 1 respectively).

References

[1] new dc, wong yh. bml-190 and am251 act as inverse agonists at the human cannabinoid cb2 receptor: signalling via camp and inositol phosphates. febs lett. 2003 feb 11;536(1-3):157-60. pubmed pmid: 12586356.
[2] chang yh, lee st, lin ww. effects of cannabinoids on lps-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids. j cell biochem. 2001;81(4):715-23. pubmed pmid: 11329626.
[3] klegeris a, bissonnette cj, mcgeer pl. reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type cb2 receptor. br j pharmacol. 2003 jun;139(4):775-86. pubmed pmid: 12813001; pubmed central pmcid: pmc1573900.
[4] scutt a, williamson em. cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via cb2 receptors. calcif tissue int. 2007 jan;80(1):50-9. epub 2007 jan 4. pubmed pmid: 17205329.
[5] zhang l, zhang x, wu p, li h, jin s, zhou x, li y, ye d, chen b, wan j. bml-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. inflamm res. 2008 apr;57(4):157-62. doi: 10. 1007/s00011-007-7141-z. pubmed pmid: 18648754.
[6] zhang q, ma p, cole rb, wang g. in vitro metabolism of indomethacin morpholinylamide (bml-190), an inverse agonist for the peripheral cannabinoid receptor (cb(2)) in rat liver microsomes. eur j pharm sci. 2010 sep 11;41(1):163-72. doi: 10.1016/j.ejps.2010.06.004. epub 2010 jun 11. pubmed pmid: 20542112; pubmed central pmcid: pmc2907062.

BML-190 Preparation Products And Raw materials

Raw materials

Preparation Products

BML-190 Suppliers

Global( 110)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	6708	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28251	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shanghai UCHEM Inc.	58
Dideu Industries Group Limited	58
BOC Sciences	58
Hefei Hirisun Pharmatech Co., Ltd	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58

View Lastest Price from BML-190 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-01	BML-190 2854-32-2	US $3.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

BML-190
2854-32-2
US $3.00 / KG
98%
Career Henan Chemical Co

BML-190 Spectrum

BML-190(2854-32-2)¹HNMR

2854-32-2(BML-190)Related Search:

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Bufotenine 5-HYDROXYINDOLE-3-ACETAMIDE 5-Methoxytryptamine Indole-3-acetic acid 2-METHYL-5-HYDROXYTRYPTAMINE

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1of4

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE 1h-indole,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-(2-(4-morpholinyl)-2-oxoe 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)-morpholin BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1-[2-(morpholinyl)-2-oxoethyl]-1H-indole 2-(1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-1H-indol-3-yl)-1-Morpholinoethanone 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-1H-indole 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-[(morpholinocarbonyl)methyl]-indole 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)ethanone Ethanone, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-1-(4-morpholinyl)- N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine IMMA INDOMETHACIN MORPHOLINYLAMIDE BML-190 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, MORPHOLINEAMIDE BML-190 (Indomethacin morpholinylamide BML-190 USP/EP/BP Indomethacin Morpholinylamide Impurity BML 190; BML190; IMMA; INDOMETHACIN MORPHOLINYLAMIDE BML-190;BML 190;BML190 Indomethacin morpholinamide 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl]-1-morpholinoethanone 2854-32-2 C23H23ClN2O4 Inhibitors Cannabinoid receptor