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Testolactone

Testolactone
Testolactone structure
CAS No.
968-93-4
Chemical Name:
Testolactone
Synonyms
sq9538;teolit;teslac;teslak;nsc-12173;NSC-23759;fludestrin;testolacton;TESTOLACTONE;Δ1-Testolactone
CBNumber:
CB4371689
Molecular Formula:
C19H24O3
Formula Weight:
300.39
MOL File:
968-93-4.mol

Testolactone Properties

Melting point:
218-219°
alpha 
D23 -45.6° (c = 1.24 in chloroform)
Boiling point:
482.0±45.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
CAS DataBase Reference
968-93-4(CAS DataBase Reference)
FDA UNII
6J9BLA949Q
NCI Drug Dictionary
Teslac
SAFETY
  • Risk and Safety Statements
HS Code  2937290000

Testolactone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0005335 TESTOLACTONE 95.00% 968-93-4 10MG $739.2 2021-12-16 Buy
American Custom Chemicals Corporation API0005335 TESTOLACTONE 95.00% 968-93-4 100MG $1871.1 2021-12-16 Buy

Testolactone Chemical Properties,Uses,Production

Originator

Fludestrin,Heyden,W. Germany,1968

Uses

Antineoplastic; non-selective steroidal aromatase inhibitor that prevents the conversion from androgen to estrogen. Used in in the treatment of familial male precocious puberty. An effective anti-tumor agent.

Uses

Testolactone USP (Teslac) is used to treat Breast cancer.

Manufacturing Process

(a) Fermentation: A medium of the following composition is prepared: 3.0 grams cornsteep liquor solids; 3.0 grams NH4H2PO4; 2.5 grams CaCO3; 2.2 grams soybean oil; 0.5 gram progesterone and distilled water to make 1 liter. The medium is adjusted to pH 7.00.1. Then, 100 ml portions of the medium are distributed in 500 ml Erlenmeyer flasks and the flasks plugged with cotton and sterilized in the usual manner (i.e., by autoclaving for 30 minutes at 120°C). When cool, each of the flasks is inoculated with 5 to 10% of a vegetative inoculum of Cylindrocarpon radicola [the vegetative inoculum being grown from stock cultures (lyophilized vial or agar slant) for 48 to 72 hours in a medium of the following composition: 15 grams cornsteep liquor; 10 grams brown sugar; 6 grams NaNO3; 0.001 gram ZnSO4; 1.5 grams KH2PO4;0.5 gram MgSO47H2O; 5 grams CaCO3; 2 grams lard oil; and distilled water to make 1 liter].
The flasks are then placed on a reciprocating shaker (120 one and one-half inch cycles per minute) and mechanically shaken at 25°C for 3 days. The contents of the flasks are then pooled and, after the pH of the culture is adjusted to about 40.2 with sulfuric acid, filtered through Seitz filter pads to separate the mycelium from the fermented medium.
(b) Extraction: 40 liters of the culture filtrate obtained in (a) is extracted with 40 liters chloroform in an extractor (e.g., Podbelniak, US Patent 2,530,886, or improvements thereon) and the filtered chloroform extract is evaporated to dryness in vacuo. The residue (11.1 grams) is taken up in 200 ml of 80% aqueous methanol, and the resulting solution is extracted four times with 100 ml portions of hexane. The 80% aqueous methanol solution is then concentrated in vacuo until crystals appear; and, after cooling at 0°C for several (usually about 3 to 4) hours, the crystals formed are recovered by filtration. About 2.9 grams 1-dehydrotestololactone (MP 217° to 217.5°C) are thus obtained. Concentration of the mother liquors yields additionally about 6.0 grams of the lactone. Recrystallization from acetone yields a purified 1-dehydrotestololactone having a melting point of 218° to 219°C.

Therapeutic Function

Cancer chemotherapy

General Description

Testolactone, 13-hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acidΔ-lactone (Teslac),was originally synthesized as a possible anabolic steroid,considering its structural similarity to testosterone. The keystructural difference from anabolic steroids is the D-ring lactone instead of the typical cyclopentyl ring. Althoughconsidered in many texts an androgen or anabolic steroid (itis a Schedule III drug because of its classification as an anabolicsteroid), testolactone lacks androgenic effects in vivo.Its action is believed to be caused by irreversible inhibitionof aromatase. It is a relatively weak inhibitor of aromatase,but the irreversible nature of the inhibition can lead to prolongedeffects. Its relatively weak inhibition of aromataseand its undesirable dosage schedule (5×50-mg tabletsq.i.d.) give this older agent only limited use in breast cancertreatment because of better available options.

Testolactone Preparation Products And Raw materials

Raw materials

Preparation Products


Testolactone Suppliers

Global( 57)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hebei shuoxi biotechnology co. LTD
+8613081092107
whatsapp:+8613081092107 julia@hbshuoxi.com CHINA 973 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58
Wuhan Aoliqisi New Material Technology Co., Ltd.
+8613545906766
sales@whaop.com China 291 58
Hebei Qige Biological Technology Co. Ltd
8618733132031
qige01@hbqige.com CHINA 1322 58
Wuhan Golt Biotech Co., Ltd.
+8615389281203
maria@goltbiotech.com China 980 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32439 55
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15424 60

View Lastest Price from Testolactone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-28 Testolactone
968-93-4
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-03-17 testolactone
968-93-4
US $0.00 / KG 1g 99.9% 1 ton Hebei shuoxi biotechnology co. LTD
2019-12-26 Testolactone
968-93-4
US $6.60 / KG 500g 98% 1kg, 50kg, 100kg Career Henan Chemical Co

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