N1-Methyl-Pseudouridine-5'-Triphosphate
- CAS No.
- 1428903-59-6
- Chemical Name:
- N1-Methyl-Pseudouridine-5'-Triphosphate
- Synonyms
- abs60156;N1-Me-pUTP;Pseudo-UTP-Na3;N1 -Me-Pseudo UTP;N1-Methylpseudo-UTP;N1-Methy-Pseudo-UTP;Cytidine Impurity 9;N1-Me-pUTP Tris salt;N1-Me-pUTP Sodium Salt;N1-Me-pUTP sodium solution
- CBNumber:
- CB48099851
- Molecular Formula:
- C10H17N2O15P3
- Molecular Weight:
- 498.17
- MDL Number:
- MOL File:
- 1428903-59-6.mol
| Density | 2.010±0.06 g/cm3(Predicted) |
|---|---|
| pka | 0.97±0.50(Predicted) |
| InChIKey | OLRONOIBERDKRE-CAYFCZNJNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r| |
| FDA UNII | 5ENC36P33M |
N1-Methyl-Pseudouridine-5'-Triphosphate Chemical Properties,Uses,Production
Color
N1-Methyl-Pseudouridine-5'-Triphosphate is a colorless to slightly yellow.
Form
N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water.
Description
N1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.
Uses
1-Methylpseudouridine-5'-triphosphate Sodium Salt is a salt analogue of 1-Methylpseudouridine-5'-triphosphate, which can be used to optimize the cardiac delivery of modified mRNA
Advantages
The substitution of U with N1-Methyl-Pseudouridine-5'-Triphosphate (m1Ψ) not only bypasses immune response induced cytotoxicity, but also substantially enhances the effectiveness of both types of switches. The m1Ψ substitution induced higher protein expression of mRNA than other modified bases, allowing clearer detection of signals and better fold-change between ON and OFF states of the switches. In addition, the m1Ψ substitution enhanced the sensitivity and performance of synthetic RNA circuit composed of both miRNA- and RBP-sensing switches[1].
References
[1] Callum J C Parr. “N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.” Nucleic Acids Research 48 6 (2020): e35.
N1-Methyl-Pseudouridine-5'-Triphosphate Preparation Products And Raw materials
Raw materials
Preparation Products
N1-Methyl-Pseudouridine-5'-Triphosphate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Zhejiang Hengkang Pharmaceutical Co., Ltd. | +86-576-83372028 +86-18868723926 | bd1@hengkangpharm.cn | China | 119 | 58 |
| Hefei Huana Biomedical Technology Co.,Ltd. | +86-15900695956 | shiqin.he@huanaok.com.cn | China | 96 | 58 |
| Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 | sales@meiyapharm.com | China | 57 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 +86-13986145403 | info@fortunachem.com | China | 5988 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
View Lastest Price from N1-Methyl-Pseudouridine-5'-Triphosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-11 | Pseudo-UTP-Na3
1428903-59-6
|
US $0.00 / ml | 100ml | HPLC：≥90.0% | 500L | Hangzhou Meiya Pharmaceutical Co Ltd | |
 |
2023-04-04 | 1-Methylpseudouridine-5'-Triphosphate
1428903-59-6
|
US $0.00-0.00 / ml | 1ml | 98% | 1000L per month | Zhejiang Hengkang Pharmaceutical Co., Ltd. | |
 |
2023-03-14 | N1-methyl-Pseudo-UTP | US $0.00 / ml | 100ml | ≥99%(HPLC) | 20000L | Hefei Huana Biomedical Technology Co.,Ltd. |
-
- Pseudo-UTP-Na3
1428903-59-6
- US $0.00 / ml
- HPLC：≥90.0%
- Hangzhou Meiya Pharmaceutical Co Ltd
-
- 1-Methylpseudouridine-5'-Triphosphate
1428903-59-6
- US $0.00-0.00 / ml
- 98%
- Zhejiang Hengkang Pharmaceutical Co., Ltd.
-
- N1-methyl-Pseudo-UTP
- US $0.00 / ml
- ≥99%(HPLC)
- Hefei Huana Biomedical Technology Co.,Ltd.