benzatropine
- CAS No.
- 86-13-5
- Chemical Name:
- benzatropine
- Synonyms
- Benaztropine;NK 02;Akitan;C06846;Cogentine;NISTC86135;benzatropine;exo-Benztropine;GIJXKZJWITVLHI-PMOLBWCYSA-N;(1S,5R)-3α-(Diphenylmethoxy)tropane
- CBNumber:
- CB4875758
- Molecular Formula:
- C21H25NO
- Molecular Weight:
- 307.4293
- MDL Number:
- MFCD00866568
- MOL File:
- 86-13-5.mol
| Boiling point | 447.93°C (rough estimate) |
|---|---|
| Density | 1.0505 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| pka | 10.54±0.40(Predicted) |
| FDA UNII | 1NHL2J4X8K |
| ATC code | N04AC01 |
| EPA Substance Registry System | 8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo)- (86-13-5) |
benzatropine Chemical Properties,Uses,Production
Description
Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970.
Uses
Benzatropine is used to reduce extrapyramidal side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, and may alleviate rigidity and bradykinesia.Benzatropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.
Side effects
These are principally anticholinergic:Dry mouth;Blurred vision;Cognitive changes;Drowsiness;Constipation;Urinary retention;Tachycardia;Anorexia;Severe delirium and hallucinations (in overdose).
Toxicity
The oral LD50 of benztropine is reported to be of 940 mg/kg in rats.In the presence of overdose with benztropine, it has been observed symptoms of circulatory collapse, cardiac arrest, respiratory depression, respiratory arrest, psychosis, shock, coma, seizure, ataxia, combativeness, anhidrosis, hyperthermia, fever, dysphagia, decreased bowel sounds and sluggish pupils.
Uses
Antiparkinsonian.
Definition
ChEBI: Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to re uce parkinsonism and akathisia side effects of antipsychotic treatments.
brand name
Cogentin (Merck).
Safety Profile
Poison by subcutaneous andintravenous routes. When heated to decomposition itemits toxic fumes of NOx.
benzatropine Preparation Products And Raw materials
Raw materials
Preparation Products
benzatropine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9309 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2487 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 3977 | 58 |