(3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride
- CAS No.
- 52211-63-9
- Chemical Name:
- (3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride
- Synonyms
- PerMiran;Quinicine;quinotoxin;Chinotoxin;ViquidilHCl;Viquidilhydrochloride;Chinicine Hydrochloride;Quinotoxine Hydrochloride;Quinine Impurity 4 Hydrochloride;(3R,4R)-4-[3-Oxo-3-(6-Methoxyquinolin-4-yl)propyl]-3-vinylpiperidine Hydrochloride
- CBNumber:
- CB4915542
- Molecular Formula:
- C20H25ClN2O2
- Molecular Weight:
- 360.8777
- MDL Number:
- MOL File:
- 52211-63-9.mol
| Melting point | 184 ±4° |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Water (Slightly, Sonicated) |
| form | Solid |
| color | Pale Yellow to Yellow |
| Water Solubility | Water: 15 mg/mL (41.57 mM) |
| Stability | Very Hygroscopic |
| FDA UNII | U6FXT2V136 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H312-H332-H302 |
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
(3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride price More Price(2)
(3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride Chemical Properties,Uses,Production
Description
Although this alkaloid from the bark of Cinchona species was first isolated by
Howard in 1871, it had earlier been prepared by Pasteur by heating the acid
sulphate of quinine and Hesse subsequently prepared it in a similar manner from
quinidine. The identity of the alkaloid with quinotoxine, formed by heating
quinine in H20 or dilute AcOH was proved by von Miller and his co-workers.
The base forms a bitter, yellow varnish having [α]D + 38.6° (CHCI 3 ) and is
normally purified through the oxalate nonahydrate which has m.p. 166-7°C;[α]20D + 24°. The alkaloid yields crystalline salts, the hydrochloride forming
colourless leaflets, m.p. l80-2°C; [α]]13.7D + 16 26° (H20); the oxime, m.p.
l12-6°C; dipicrolonate, m.p. 210°C; the (+)-tropate monohydrate, m.p.
l12-3°C or l16-8°C (dry). The p-bromophenylhydrazone forms yellow
crystals, m.p. 141°C. Both the N-methyl and N-ethyl derivatives are yellow oils,
the former yielding a hydrochloride monohydrate, m.p. l53-5°C; [α]23D + 16.6°
(H20) and the latter the corresponding hydrochloride, m.p. 202-4°C; [α]23D +
68.1 ° (H20). The N-benzoyl derivative crystallizes from C6H6 or MeOH with
m.p. l13-4°C; [α]22D + 36° (c 2.0, EtOH).
According to de Caro, the minimum lethal dose for white rats is 0.32 gm/kilo
compared with 1.25 gm/kilo for quinine and, although it has no anti-malarial
action, the alkaloid appears to be less toxic than formerly supposed.
Uses
An isomer of quinine; occurs naturally as the d-form. Present in small quantities in cinchona barks. Vasodilator (cerebral).
Uses
An isomer of quinine; occurs naturally as the d-form. Present in small quantities in cinchona barks. Vasodilator (cerebral).
References
Pasteur.,Jahresb., 473 (1853)
Howard.,f. Chem. Soc., 24, 6! (! 871)
Howard., ibid, 25, 101 (1872)
Hesse., Annalen, 178, 244 (1875)
von Miller, Rohde, Fussenegger., Ber., 33,3228 (1900)
Heidelberger, Jacobs.,J. Amer. Chem. Soc., 41,832 (1919)
Heidelberger, Jacobs., ibid, 44, 1093 (1922)
Frankel, Diamant., Ber., 58,554 (1925)
Prostenik, Prelog., Helv. Chim. Acta, 26, 1965 (1943)
Toxicology :
de Caro., Arch. expo Path. Pharm., 164,314 (1932)
(3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(3R-cis)-1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)propan-1-one monohydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1785 | 58 | |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 7590 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9506 | 60 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 3004654993@qq.com | China | 9175 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55827 | 58 |
| Shanghai Yanze Chemical Co., Ltd. | 021-13773155751 19901447308 | 260924549@qq.com | China | 8576 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |