PROTAC AR-V7 degrader-1
- CAS No.
- 2767440-24-2
- Chemical Name:
- PROTAC AR-V7 degrader-1
- Synonyms
- PROTAC AR-V7 degrader-1
- CBNumber:
- CB512335825
- Molecular Formula:
- C41H52N6O6S2
- Molecular Weight:
- 789.02
- MDL Number:
- MOL File:
- 2767440-24-2.mol
PROTAC AR-V7 degrader-1 Chemical Properties,Uses,Production
Uses
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 μM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 μM[1].
IC 50
VHL
References
[1] Archana Bhumireddy,?et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett.?2022 Jan 1;55:128448. DOI:10.1016/j.bmcl.2021.128448
PROTAC AR-V7 degrader-1 Preparation Products And Raw materials
Raw materials
Preparation Products
PROTAC AR-V7 degrader-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 2997 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5002 | 58 |
| Lucheng (Shenzhen) Technology Co., Ltd. | 13128698830 | CHINA | 181 | 58 |
| Supplier | Advantage |
|---|---|
| Nantong Hi-Future Biotechnology Co., Ltd | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 58 |
| Lucheng (Shenzhen) Technology Co., Ltd. | 58 |
