α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide
![α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide Structure](CAS/20211123/GIF/2883115-46-4.gif)
- CAS No.
- 2883115-46-4
- Chemical Name:
- α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide
- Synonyms
- ML162-yne;α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide;2-Chloro-N-(3-chloro-4-(prop-2-yn-1-yloxy)phenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
- CBNumber:
- CB513322356
- Molecular Formula:
- C25H22Cl2N2O3S
- Molecular Weight:
- 501.42
- MDL Number:
- MOL File:
- 2883115-46-4.mol
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide Properties
| Boiling point | 719.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.346±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
| solubility | DMSO: Soluble: =10 mg/ml |
| form | Solid |
| pka | 13.83±0.46(Predicted) |
| color | White to off-white |
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide Chemical Properties,Uses,Production
Uses
ML162-yne is a potent GPX4-inhibitor affinity probe[1]. ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
References
[1] Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020 May;16(5):497-506. DOI:10.1038/s41589-020-0501-5
[2] TIANLI LUO. Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo[J]. Angewandte Chemie International Edition, 2022, 61 39. DOI: 10.1002/anie.202206277
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 7342 | 55 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4755 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| JiNan QiYuan Biotechnology Co., Ltd | 18766124282; 18766124282 | 18766124282@163.COM | China | 929 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13011 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
