ChemicalBook >> CAS DataBase List >>pyridine-3-sulfonyl chloride
pyridine-3-sulfonyl chloride
- CAS No.
- 16133-25-8
- Chemical Name:
- pyridine-3-sulfonyl chloride
- Synonyms
- 3-Pyridine sulphonyl chloride;m-Pyridinesulfonyl chloride;3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE;PYRIDINE-3-SULPHONYL CHLORIDE HYDROCHLORIDE;Vonoprazan-8;Vonoprazan-029;TAK438 Impurity 68;Vonolazan impurity 8;Vonoprazan Impurity 50;Vonoprazan intermediate
- CBNumber:
- CB5153121
- Molecular Formula:
- C5H4ClNO2S
- Molecular Weight:
- 177.61
- MDL Number:
- MFCD04035552
- MOL File:
- 16133-25-8.mol
- MSDS File:
- SDS
Last updated:2024-03-07 10:36:35
| Melting point | 144 °C |
|---|---|
| Boiling point | 284℃ |
| Density | 1.488 |
| Flash point | 126℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | liquid |
| pka | -1.77±0.11(Predicted) |
| color | Colourless to light yellow |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C5H4ClNO2S/c6-10(8,9)5-2-1-3-7-4-5/h1-4H |
| InChIKey | CDRNYKLYADJTMN-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1S(Cl)(=O)=O |
| LogP | 1.75 |
| CAS DataBase Reference | 16133-25-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05, GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H317 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Hazard Codes | Xi,C |
| Risk Statements | 34-43 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | 3261 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| PackingGroup | Ⅲ |
| HS Code | 2933399990 |
pyridine-3-sulfonyl chloride price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS013908 | 3-pyridinesulfonyl chloride hydrochloride Aldrich | 16133-25-8 | 250mg | $124 | 2024-03-01 | Buy |
| Sigma-Aldrich | 749273 | Pyridine-3-sulfonyl chloride 95% | 1G | $48.4 | 2023-06-20 | Buy | |
| TRC | P991565 | 3-pyridinesulfonylChloride | 16133-25-8 | 5g | $60 | 2021-12-16 | Buy |
| Apolloscientific | OR951579 | Pyridine-3-sulfonylchloride 98% | 16133-25-8 | 25g | $88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0146974 | 3-PYRIDINE SULFONYL CHLORIDE 95.00% | 16133-25-8 | 1G | $721.57 | 2021-12-16 | Buy |
pyridine-3-sulfonyl chloride Chemical Properties,Uses,Production
Uses
3-pyridinesulfonyl Chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Application
Pyridine-3-sulfonyl chloride is an essential medical intermediate and is widely applied to the synthesis of medicines, wherein the pyridine-3-sulfonyl chloride is mainly used for preparing TAK-438 (vonoprazan fumarate), which is a novel orally active potassium-competitive acid blocker, developed as an antisecretory drug.
Toxicology
Pyridine-3-sulfonyl chloride causes burns of eyes, skin and mucous membranes. Contact with water liberates toxic gas.
Synthesis
Add thionyl chloride to the water, cool to about 0-5°C, and add cuprous chloride. Fluoboric acid diazonium salt was added to the solution and reacted at 0-5°C overnight. The reaction solution was extracted with dichloromethane, combining the organic layers. The organic layer was washed once with saturated aqueous sodium bicarbonate solution, once with water, and finally once with saturated brine. The product was dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated to remove methylene chloride to obtain the product pyridine-3-sulfonyl chloride with a yield of 90.7%.
pyridine-3-sulfonyl chloride Preparation Products And Raw materials
Global( 478)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ningbo Polysyn Pharmatech Co.,Ltd | +8615706225626 | BD@polysyn.cn | China | 82 | 58 |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
| Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 228 | 58 |
| Changsha Junyu Chemexpress.co., Ltd | +86-13723890100 | info@csjyyy.cn | China | 134 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Shandong Huisheng Import & Export Co., Ltd. | +86-13176845580 +86-13176845580 | da@zhongda-biotech.com | China | 248 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
View Lastest Price from pyridine-3-sulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | pyridine-3-sulfonyl chloride
16133-25-8
|
US $100.00-60.00 / kg | 100kg | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-04-10 | 3-Pyridinesulfonyl chloride
16133-25-8
|
US $0.00 / kg | 1kg | 98% | 100kg | Shanghai Joiny Pharmaceutical Co.,LTD | |
 |
2024-04-10 | 3-Pyridinesulfonyl chloride
16133-25-8
|
US $0.00 / kg | 1kg | 98% | 50kg | Shanghai Joiny Pharmaceutical Co.,LTD |
-
- pyridine-3-sulfonyl chloride
16133-25-8
- US $100.00-60.00 / kg
- 99.99%
- Hebei Dangtong Import and export Co LTD
-
- 3-Pyridinesulfonyl chloride
16133-25-8
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 3-Pyridinesulfonyl chloride
16133-25-8
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
16133-25-8(pyridine-3-sulfonyl chloride )Related Search:
PYRIDINE-4-SULFONYL CHLORIDE
1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester
1H-Pyrrole-3-methanamine, 1-[(1,4-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl-
1H-Pyrrole-3-methanamine, 1-[(1,6-dihydro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-N-methyl-
5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
1-(5-(2-fluorophenyl)-1H-pyrrol-3-yl)-N-methylmethanamine
5-(4-fluorophenyl)-1H-pyrrole-3-carbonitrile
PYRIDINE-2-SULFONIC ACID
1-methylpyridin-1-ium-4-sulfonate
(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol
1of4
3-CHLOROSULFONYL-PYRIDINIUM, CHLORIDE
3-PYRIDINESULFONYL CHLORIDE, HCL
Piperidine-3-sulfonylchloride
Vonoprazan intermediate
pyridine-3-sulfonyl chloride(SALTDATA: 0.8HCl 0.3H2O)
Vonoprazan-8
Vonoprazan-029
Vonoprazan Impurity 50
PYRIDINE-3-SULFONYL CHLORIDE HYDROCHLO
Vonoprazan Fumarate impurity P
TAK438 Impurity 68
3-CHLOROSULFONYL-PYRIDINIUM
Pyridine-3-Sulphonyl Chloride
Pyridine 3 Sulfonic Acid Chloride
PYRIDINE-3-SULFONYL CHLORIDE HYDROCHLORIDE ISO 9001：2015 REACH
Vonoprazan fumarate intermediates
3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE
PYRIDINE-3-SULPHONYL CHLORIDE HYDROCHLORIDE
3-Pyridine sulphonyl chloride
m-Pyridinesulfonyl chloride
chloro-3-pyridylsulfone
PYRIDINE-3-SULFONYL CHLORIDE
3-Pyridinesulfonyl chloride (6CI, 8CI, 9CI, ACI)
yridine-3-sulfonyl chloride
3-pyridinesulfonyl chloridde
Vonolazan impurity 8
Pyridine-3-sulfony chloride
16133-25-8
161-25-8
16133-25-8