Chinese Japanese Germany


Chemical Properties Application Production Healthy effects Toxicity Storage
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

N,N-Dimethylformamide Properties

Melting point:
-61 °C
0.94 º
Boiling point:
153 °C(lit.)
0.948 g/mL at 20 °C
vapor density 
2.5 (vs air)
vapor pressure 
2.7 mm Hg ( 20 °C)
refractive index 
n20/D 1.430(lit.)
Flash point:
136 °F
storage temp. 
Store at RT.
water: miscible
APHA: ≤15
Relative polarity
7 (200g/l, H2O, 20℃)
explosive limit
Water Solubility 
CAS DataBase Reference
68-12-2(CAS DataBase Reference)
NIST Chemistry Reference
Formamide, N,N-dimethyl-(68-12-2)
EPA Substance Registry System
Formamide, N,N-dimethyl-(68-12-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  61-20/21-36
Safety Statements  53-45
RIDADR  UN 2265 3/PG 3
WGK Germany  1
RTECS  LQ2100000
Hazard Note  Toxic
HazardClass  3
PackingGroup  III
HS Code  29241990
Hazardous Substances Data 68-12-2(Hazardous Substances Data)
Toxicity LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

N,N-Dimethylformamide price More Price(124)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1601500 Residual Solvent Class 2 - N,N-Dimethylformamide Pharmaceutical Secondary Standard; Certified Reference Material 68-12-2 3x1.2ml $67.5 2018-11-13 Buy
Sigma-Aldrich 227056 N,N-Dimethylformamide anhydrous, 99.8% 68-12-2 6x1l $510 2018-11-13 Buy
TCI Chemical D0722 N,N-Dimethylformamide >99.5%(GC) 68-12-2 25mL $15 2018-11-22 Buy
TCI Chemical D0722 N,N-Dimethylformamide >99.5%(GC) 68-12-2 100mL $18 2018-11-22 Buy
Alfa Aesar 013808 N,N-Dimethylformamide, Spectrophotometric Grade, 99.7+% 68-12-2 1L $55.5 2018-11-16 Buy

N,N-Dimethylformamide Chemical Properties,Uses,Production

Chemical Properties

Dimethylformamide is shorted for DMF. It is a compound formed by the substitution of the formic acid's hydroxyl group with dimethylamino group and the molecular formula HCON(CH3)2. It is a clear, transparent, high-boiling point liquid with a light amine flavor and a relative density of 0.9445 (25°C). React violently with concentrated sulfuric acid, fuming nitric acid and can even explode. It is soluble in water and most organic solvents that used as a common solvent for chemical reactions. Pure Dimethylformamide is odorless, but industrial grade or modified Dimethylformamide has a fishy smell because it contains impurities of Dimethylamine. Dimethylformamide is unstable (especially at high temperatures) in the presence of a strong base such as sodium hydroxide or a strong acid such as hydrochloric acid or sulfuric acid, and is hydrolyzed to formic acid and dimethylamine.


The primary use of DMF is as a solvent with low evaporation rate. It is commonly used in industrial reactions and in laboratory that could be listed as follows:
Field Uses
Bouveault aldehyde synthesis and Vilsmeier-Haack reaction As a reagent and another useful method of forming aldehydes.
Heck reaction Common solvent
Recovery of olefins such as 1,3-butadiene via extractive distillation     Solvent  
Manufacture of adhesives, synthetic leathers, fibers, films, pesticides and and surface coatings
Synthesis of acyl halides Common catalyst
Manufacture of solvent dyes Important raw material
Compressing industrial acetylene to form a safe, concentrated solution Reagent
Petroleum Industry A gas absorbent for separating and refining gases
Polyurethane industry As a cleaning agent in wet synthetic leather production
Nitrile industry As a solvent in dry spinning of acrylic fibers
Electronic industry As tin-plated parts quenching and circuit board cleaning agent
Pesticide and Pharmaceutical industries An important intermediate of organic synthesis
  In laborary
Field/Properties Application
Separating and suspending carbon nanotubes Recommended by the NIST for use in near infrared spectroscopy
Allowing for a quantitative determination of an unknown compound. As a standard in proton NMR spectroscopy
Synthesis of organometallic compounds A source of carbon monoxide ligands
Electrospinning Common solvent
Solvothermal synthesis of Metal Organic Frameworks Reagent


DMF was first prepared in 1893 by the French chemist Albert Verley (8 January 1867 – 27 November 1959), by distilling a mixture of dimethylamine hydrochloride and potassium formate.
After that, different synthesis methods using a variety of raw materials have been developed, such as the dimethylamine-carbon monoxide method, the formamide-dimethylamine method, Hydrocyanic acid-methanol method, acetonitrile-methanol method, methyl formate-dimethylamine method, trichloroacetaldehyde-dimethylamine method, and the like. However, the current industrial production is still dominated by the dimethylamine-carbon monoxide method.  The major production methods are concluded as follows: 
1. Methyl formate-dimethylamine method: Esterification of formic acid with methanol to produce methyl formate, followed by reaction with dimethylamine in the gas phase to produce dimethylformamide, and distillation followed by recovery of methanol and unreacted methyl formate to reduce Pressure rectification products. 
2. Dimethylamine-Carbon Monoxide Method: Obtained directly from the reaction of dimethylamine and carbon monoxide in the presence of sodium methoxide. The reaction conditions are 1.5-2.5 MPa and 110-150°C. The crude product is obtained through rectification to obtain the finished product. 
3. Induce carbonyl synthesis of methyl monoxide and methanol at high pressure and 80-100 °C temperature to produce methyl formate, and then reacts with dimethylamine to produce dimethylformamide. After distillation, the finished product is obtained. 
4. Obtained from the reaction of trichloroacetaldehyde and dimethylamine.

Healthy effects

Overexposure to DMF could result in hepatotoxicity, alcohol intolerance, possible embryotoxicity and teratogenicity in humans and animals, and decline of human sperm motility. 
The current permissible exposure limit for DMF in the working environment is 10 ppm in both USA and Taiwan. The concentrations of two major DMF metabolites in urine, N-methylformamide (U-NMF) of 15 mg/L and N-acetyl-S-(N-methylcarbamoyl) cysteine (U-AMCC) of 40 mg/L, were recommended as the biological exposure indices (BEIs) by the American Conference of Governmental Industrial Hygienists for DMF exposure in workplace.
Acute Effects
Symptoms of acute exposure in humans include abdominal pain, nausea, vomiting, jaundice, alcohol intolerance, and rashes. 
Chronic Effects
Chronic (long-term) occupational exposure to dimethylformamide by inhalation has resulted in effects on the liver and digestive disturbances in workers. 
Human Studies have shown a possible link to cancer from chronic, occupational exposure to dimethylformamide.


The acute LD50 (oral, rats and mice) is 2.2-7.55 mg/kg.[6] Hazards of DMF have been examined.


DMF is stable. It is hygroscopic and easily absorbs water form a humid atmosphere and should therefore be kept under dry nitrogen. High purity DMF, required for acrylic fibers, is best stored in aluminum tanks. DMF does not change under light or oxygen and does not polymerize spontaneously. Temperatures >350 deg C may cause decomposition to form dimethylamine and carbon dioxide, with pressure developing in closed containers.

Chemical Properties

Clear colorless liquid


N,N-Dimethylformamide (DMF) is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents.
  1. Dimethylformamide is primarily used as an industrial solvent.  Dimethylformamide solutions are used toprocess polymer fibers, films, and surface coatings; to permit easy spinning of acrylic fibers; to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.
  2. DMF can also be used for formylation with alkyllithium or Grignard reagents.
  3. It is used as a reagent in Bouveault aldehyde synthesis and also in Vilsmeier-Haack reaction. It acts as a catalyst in the synthesis of acyl chlorides. It is used for separating and refining crude from olefin gas. DMF along with methylene chloride acts as a remover of varnish or lacquers. It is also used in the manufacture of adhesives, fibers and films.
  4. N,N-Dimethylformamide (DMF) is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in molecular biology applications.
  5. N,N-Dimethylformamide was used to solubilize MTT crystals in cell viability assays.It was also used in feruloyl esterase activity assay in molds exhibiting high activity of the enzyme.
  6. The world-wide consumption of DMF in 2001 was approximately 285, 000 metric tonnes and most of that was used as an industrial solvent.


Solvent for many hydrophobic organic compounds.


ChEBI: A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.


Solvent for liqs and gases. In the synthesis of organic compounds. Solvent for Orlon and similar polyacrylic fibers. Wherever a solvent with a slow rate of evaporation is required. Has been termed the universal organic solvent.

General Description

A water-white liquid with a faint fishy odor. Flash point 136°F. Slightly less dense than water. Vapors heavier than air. Toxic by inhalation or skin absorption. May irritate eyes.

Air & Water Reactions

Flammable. Water soluble.

Reactivity Profile

N,N-Dimethylformamide may react violently with a broad range of chemicals, e.g.: alkaline metals (sodium, potassium), azides, hydrides (sodium borohydride, lithium aluminum hydride), bromine, chlorine, carbon tetrachloride, hexachlorocyclohexane, phosphorus pentaoxide, triethylaluminum, magnesium nitrate, organic nitrates. Forms explosive mixtures with lithium azide [Bretherick, 5th ed., 1995, p. 453]. Oxidation by chromium trioxide or potassium permanganate may lead to explosion [Pal B. C. et al., Chem. Eng. News, 1981, 59, p. 47].

Health Hazard

Irritation of eyes, skin and nose. May cause nausea.

Health Hazard

The acute toxicity of DMF is low by inhalation, ingestion, and skin contact. Contact with liquid DMF may cause eye and skin irritation. DMF is an excellent solvent for many toxic materials that are not ordinarily absorbed and can increase the hazard of these substances by skin contact. Exposure to high concentrations of DMF may lead to liver damage and other systemic effects. Dimethylformamide is listed by IARC in Group 2B ("possible human carcinogen"). It is not classified as a "select carcinogen" according to the criteria of the OSHA Laboratory Standard. No significant reproductive effects have been observed in animal tests. Repeated exposure to DMF may result in damage to the liver, kidneys, and cardiovascular system

Fire Hazard

Special Hazards of Combustion Products: Vapors are irritating

Fire Hazard

DMF is a combustible liquid (NFPA rating = 2). Vapors are heavier than air and may travel to source of ignition and flash back. DMF vapor forms explosive mixtures with air at concentrations of 2.2 to 15.2% (by volume). Carbon dioxide or dry chemical extinguishers should be used to fight DMF fires.

Contact allergens

This is an organic solvent for vinyl resins and acetylene, butadiene, and acid gases. It caused contact dermatitis in a technician at an epoxy resin factory and can provoke alcohol-induced flushing in exposed subjects.

Safety Profile

Suspected carcinogen. Moderately toxic by ingestion, intravenous, subcutaneous, intramuscular, and intraperitoneal routes. Mildly toxic by skin contact and inhalation. Experimental teratogenic and reproductive effects. A skin and severe eye irritant. Human mutation data reported. Flammable liquid when exposed to heat or flame; can react with oxidzing materials. Explosion hazard when exposed to flame. Explosive reaction with bromine, potassium permanganate, triethylaluminum + heat. Forms explosive mixtures with lithium azide (shock-sensitive above 2OO0C), uranium perchlorate. Igrution on contact with chromium trioxide. Violent reaction with chlorine, sodium hydroborate + heat, dusocyanatomethane, carbon tetrachloride + iron, 1,2,3,4,5,6 hexachlorocyclohexane + iron. Vigorous exothermic reaction with magnesium nitrate, sodum + heat, sodium hydride + heat, sulfinyl chloride + traces of iron or zinc, 2,4,6-trichloro-l,3,5-triazine (with gas evolution), and many other materials. Avoid contact with halogenated hydrocarbons, inorganic and organic nitrates, (2,5-diethyl pyrrole + P(OCl)3), cGCl6, methylene dusocyanates, P203. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx

Purification Methods

DMF decomposes slightly at its normal boiling point to give small amounts of dimethylamine and carbon monoxide. The decomposition is catalysed by acidic or basic materials, so that even at room temperature DMF is appreciably decomposed if allowed to stand for several hours with solid KOH, NaOH or CaH2. If these reagents are used as dehydrating agents, therefore, they should not be refluxed with the DMF. Use of CaSO4, MgSO4, silica gel or Linde type 4A molecular sieves is preferable, followed by distillation under reduced pressure. This procedure is adequate for most laboratory purposes. Larger amounts of water can be removed by azeotropic distillation with *benzene (10% v/v, previously dried over CaH2), at atmospheric pressure: water and *benzene distil below 80o. The liquid remaining in the distillation flask is further dried by adding MgSO4 (previously ignited overnight at 300-400o) to give 25g/L. After shaking for one day, a further quantity of MgSO4 is added, and the DMF is distillied at 15-20mm pressure through a 3-ft vacuum-jacketed column packed with steel helices. However, MgSO4 is an inefficient drying agent, leaving about 0.01M water in the final DMF. More efficient drying (to around 0.001-0.007M water) is achieved by standing with powdered BaO, followed by decanting before distillation, then with alumina powder (50g/L, previously heated overnight to 500-600o), and distilling from more of the alumina, or by refluxing at 120-140o for 24hours with triphenylchlorosilane (5-10g/L), then distilling at ca 5mm pressure [Thomas & Rochow J Am Chem Soc 79 1843 1957]. Free amine in DMF can be detected by the colour reaction with 1-fluoro-2,4-dinitrobenzene. It has also been purified by drying overnight over KOH pellets and then distilling from BaO through a 10 cm Vigreux column (p 11) [Jasiewicz et al. Exp Cell Res 100 213 1976]. [For efficiency of desiccants in drying dimethylformamide see Burfield & Smithers J Org Chem 43 3966 1978, and for a review on purification, tests of purity and physical properties, see Juillard Pure Appl Chem 49 885 1977.] It has been purified by distilling from K2CO3 under high vacuum and fractionated in an all-glass apparatus. The middle fraction is collected, degassed (seven or eight freeze-thaw cycles) and redistilled under as high a vacuum as possible [Mohammad & Kosower J Am Chem Soc 93 2713 1971]. [Beilstein 4 IV 171.] Rapid purification: Stir over CaH2 (5% w/v) overnight, filter, then distil at 20mmHg. Store the distilled DMF over 3A or 4A molecular sieves. For solid phase synthesis, the DMF used must be of high quality and free from amines.

N,N-Dimethylformamide Preparation Products And Raw materials

Raw materials

Preparation Products

N,N-Dimethylformamide Suppliers

Global( 437)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1582 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 CHINA 417 50
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 China 19958 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22063 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880086 CHINA 560 58
Kono Chem Co., Ltd
+86-132 8924 6953 CHINA 2164 58
career henan chemical co
+86-371-86658258 CHINA 20001 58
hebei chisure biotechnology co.,ltd
0311 66567340
0311 66567340 CHINA 403 58

View Lastest Price from N,N-Dimethylformamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-20 N,N-Dimethylformamide
US $10.00 / KG 10G 99% 500kg/month hebei chisure biotechnology co.,ltd
2018-08-07 N,N-Dimethylformamide
US $10.00 / KG 1KG 99% 100 MT per month Hebei Guanlang Biotechnology Co., Ltd.
2018-08-07 N,N-Dimethylformamide
US $1.00 / KG 1KG 99% Customized career henan chemical co

N,N-Dimethylformamide Spectrum

68-12-2(N,N-Dimethylformamide)Related Search:

Copyright 2017 © ChemicalBook. All rights reserved