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PHOSPHORAMIDON

PHOSPHORAMIDON structure

CAS No.: 119942-99-3

Chemical Name:: PHOSPHORAMIDON

Synonyms: NSC 694280;PHOSPHORAMIDON;PhosphoraMidon sodiuM;PHOSPHATIDYL DIPEPTIDE;Phophoramidon disodium;PhosphoraMidon disodiuM sa;Phosphoramidon disodium salt;PhosphoraMidon research grade;PhosphoD23-RAMidon disodiuM salt;N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL&

CBNumber:: CB5184723

Molecular Formula:: C23H35N3NaO10P

Molecular Weight:: 567.51

MDL Number:: MFCD00080262

MOL File:: 119942-99-3.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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PHOSPHORAMIDON Properties

storage temp.	-20°C
solubility	H₂O: 1 mM Stock solution stable for 1 month at –20° C.
form	Solid
color	White to pale yellow
BRN	8105669
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 2 months.
FDA UNII	T3G94E2LB1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
Safety Statements	22-24/25
WGK Germany	3
F	10-21
HS Code	2940000080

PHOSPHORAMIDON price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R7385	Phosphoramidon disodium salt ≥97% (HPLC)	119942-99-3	0.5mg	$83.7	2024-03-01	Buy
Sigma-Aldrich	R7385	Phosphoramidon disodium salt ≥97% (HPLC)	119942-99-3	1mg	$144	2024-03-01	Buy
Sigma-Aldrich	525276	Phosphoramidon, Disodium Salt Inhibits some metalloendopeptidases.		5mg	$272	2024-03-01	Buy
Alfa Aesar	J63456	Phosphoramidon disodium salt, 97+%	119942-99-3	5mg	$336.65	2024-03-01	Buy
Sigma-Aldrich	R7385	Phosphoramidon disodium salt ≥97% (HPLC)	119942-99-3	5mg	$324	2024-03-01	Buy

Product number	Packaging	Price	Buy
R7385	0.5mg	$83.7	Buy
R7385	1mg	$144	Buy
525276	5mg	$272	Buy
J63456	5mg	$336.65	Buy
R7385	5mg	$324	Buy

PHOSPHORAMIDON Chemical Properties,Uses,Production

Description

Phosphoramidon (119942-99-3) inhibits neutral endopeptidase 24.11 (NEP; Neprilysin; EC 3.4.24.11), Ki=2 nM.1?Also inhibits neprilysin 2 (Ki~2 nM).2?Also inhibits endothelin-converting enzyme (IC50?= 0.68 μM).3?Induces a dramatic increase in amyloid-beta levels in rodents.4

Uses

An endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.

Uses

Phosphoramidon is an inhibitor of NEP 24.11 and NEP2. It is an inhibitor of the enzyme thermolysin, a membrane metallo-endopeptidase inhibitor, and an endothelin converting enzyme inhibitor.

General Description

Phosphoramidon [N-(α-rhamnopyranosyl-oxyhydroxyphosphinyl)-Leu-Trp] is a competitive inhibitor of several soluble zinc metalloproteases. Phosphoramidate is produced naturally by Streptomyces?tanashiensis.

Biochem/physiol Actions

Phosphoramidon can inhibit ZMPSTE24, an integral membrane protein zinc metalloprotease. It is capable of blocking thermolysin.

References

1) Stephenson and Kenny et al. (1987),?The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11.; Biochem. J.,?243?183. 2) Rose?et al.?(2002),?Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin; Biochem. J.,?363?697 3) Ahn?et al.?(1998),?Soluble human endothelin-converting enzyme-1: expression, purification, and demonstration of pronounced pH sensitivity; Arch. Biochem. Biphys.,?359?258 4) Marr and Hafez (2014),?Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance; Front. Aging Neurosci.,?6?187

PHOSPHORAMIDON Preparation Products And Raw materials

Raw materials

Preparation Products

PHOSPHORAMIDON Suppliers

Global( 131)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3116	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
LEAP CHEM CO., LTD.	58

View Lastest Price from PHOSPHORAMIDON manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-16	PhosphoraMidon 119942-99-3	US $1.00-0.00 / KG	1KG	99%	20 tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	Phosphoramidon disodium salt 119942-99-3	US $1.00 / kg	1kg	95%-99%	1000kg	Career Henan Chemical Co

PhosphoraMidon
119942-99-3
US $1.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Phosphoramidon disodium salt
119942-99-3
US $1.00 / kg
95%-99%
Career Henan Chemical Co

119942-99-3(PHOSPHORAMIDON)Related Search:

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L-ALANYL-L-TRYPTOPHAN PHOSPHORAMIDON--N/H PHOSPHORAMIDON NA 2H20

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N-(A-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP N-(ALPHA-RHAMNOPYRANOSYLOXYHYDROXYPHOSPHINYL)-LEU-TRP-OH PHOSPHORAMIDON n-(α-rhamno-pyranosyl-oxy-hydroxy-phosphinyl)-leu-trp disodium salt PHOSPHORAMIDON SODIUM SALT, FROM MICROBIAL SOURCE N-(alpha-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt N-(alpha-rhamnopyranosylphos.)-L-leucyl-L-tryp. disod. salt N-(A-rhamnopyranosyloxyhydroxy-*phosphinyl)-leu-T N-(ALPHA-RHAMNOPYRANOSYLPHOS.)-L-LEUCYL& PHOSPHATIDYL DIPEPTIDE N-[[(6-Deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl- L-tryptophan Disodium Salt NSC 694280 N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt, N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp disodium salt N-(α-Rhamnopyranosylphosphono)-L-leucyl-L-tryptophan disodium salt Phosphoramidon disodium salt PhosphoraMidon disodiuM sa N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-Leu-Trp PhosphoraMidon research grade PhosphoD23-RAMidon disodiuM salt PhosphoraMidon sodiuM Phosphoramidon disodium salt, ≥97% (HPLC) L-Tryptophan,N-[[(6-deoxy-a-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl-,sodium salt (9CI) Phophoramidon disodium disodium,3-(1H-indol-3-yl)-2-[[4-methyl-2-[[oxido-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]pentanoyl]amino]propanoate 119942-99-3 C23H34N3O10P C23H32N3Na2O10P C23H32N3O10P2Na2H2O Enzymes, Inhibitors, and Substrates Enzyme Inhibitors by Type Enzyme Inhibitors Enzyme Inhibitors by Enzyme Phosphodiesterase 3',5'-Cyclic Nucleotide P to Q Substrate Analogs BioChemical Biochemicals and Reagents peptides inhibitor Pepetides Chiral Reagents Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Phosphorylating and Phosphitylating Agents