N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
- CAS No.
- 917369-31-4
- Chemical Name:
- N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
- Synonyms
- Azixa;EP-128495;MPC 6827 hydrochloride;Verubulin hydrochloride;Verubulin hydrochloride (MPC-6827 hydrochloride);N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine hydrochloride;N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride;MPC-6827,Microtubule/Tubulin,Verubulin,Verubulin hydrochloride,MPC 6827,inhibit,MPC6827,Inhibitor
- CBNumber:
- CB52510098
- Molecular Formula:
- C17H17N3O.HCl
- Molecular Weight:
- 315.79732
- MDL Number:
- MFCD22741413
- MOL File:
- 917369-31-4.mol
- MSDS File:
- SDS
| storage temp. | Desiccate at RT |
|---|---|
| solubility | ≥10.55 mg/mL in DMSO; ≥28.1 mg/mL in EtOH; ≥5 mg/mL in H2O |
| form | Powder |
| FDA UNII | 33380QZ0QW |
| NCI Drug Dictionary | Azixa |
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5231 | MPC6827hydrochloride ≥98%(HPLC) | 917369-31-4 | 10 | $210 | 2021-12-16 | Buy |
| Tocris | 5231 | MPC6827hydrochloride ≥98%(HPLC) | 917369-31-4 | 50 | $862 | 2021-12-16 | Buy |
| Usbiological | 255894 | MPC 6827 hydrochloride | 917369-31-4 | 10mg | $466 | 2021-12-16 | Buy |
| TRC | M326508 | MPC6827Hydrochloride | 917369-31-4 | 2.5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0003074 | Verubulinhydrochloride 98.27% | 917369-31-4 | 1mg | $130 | 2021-12-16 | Buy |
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Chemical Properties,Uses,Production
Uses
MPC 6827 Hydrochloride is a microtubule destabilizing agent which may be used in the treatment of patients with cancer.
Biological Activity
mpc-6827 (azixa) is a small-molecule microtubule-destabilizing agent that binds to the same (or nearby) sites on β-tubulin as colchicine.[1]tubulin is a heterodimer consisting of an αand βmonomer, it can be covalently labeled with [3h] colchicine by near uv irradiation. most of the label appears in β tubulin. colchicine binds to tubulin with a stoichiometry of one and inhibits microtubule assembly substoichiometrically. colchicine binding to tubulin exhibits pseudoirreversible kinetics; it displays a fast step followed by a slow step involving conformational changes of both ligand and tubulin. the tubulin, in turn, promotes fluorescence characteristic of the tropolone moiety of colchicine. [2]mpc-6827 is a small-molecule microtubule-destabilizing agent that causes mitotic arrest and cell death. mpc-6827 interfere with microtubule dynamics, leading to arrest of dividing cells in the g2-m phase of the cell cycle, which eventually results in apoptotic cell death.[1]
in vivo
mpc-6827 significantly inhibits the growth of various subcutaneously implanted tumor lines. mpc-6827 has also been shown to be a vascular-disrupting agent (vda) in a human ovarian carcinoma xenograft model. it also has shown synergism with carboplatin in a mouse xenograft model. furthermore, mpc-6827 has been shown to inhibit the growth of human glioblastoma tumor cell line (d-54) implanted intracranially in athymic nude mice. [1]
storage
Desiccate at RT
References
[1] tsimberidou am1, akerley w, schabel mc, etal. , phase i
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3238 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 13515979683 | sales@jamxmpharmatech.com | China | 1079 | 58 |