2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine
- CAS No.
- 1333222-12-0
- Chemical Name:
- 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine
- Synonyms
- 6-(Difluoromethoxy)pyridin-3-ylboronic acid pinacol ester;2-(difluoromethoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [D27707]
- CBNumber:
- CB52516540
- Molecular Formula:
- C12H16BF2NO3
- Molecular Weight:
- 271.07
- MDL Number:
- MFCD18909371
- MOL File:
- 1333222-12-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | D126070 | 10mg | $45 |
| 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97% | D27707 | 100mg | $170 |
| 2-(DIFLUOROMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 95.00% | BOR0006374 | 5MG | $504.66 |
| 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97% | D27707 | 1g | $670 |
| 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | 9880BB | 250mg | $816 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D126070 | 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | 1333222-12-0 | 10mg | $45 | 2021-12-16 | Buy |
| Synthonix | D27707 | 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97% | 1333222-12-0 | 100mg | $170 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BOR0006374 | 2-(DIFLUOROMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 95.00% | 1333222-12-0 | 5MG | $504.66 | 2021-12-16 | Buy |
| Synthonix | D27707 | 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97% | 1333222-12-0 | 1g | $670 | 2021-12-16 | Buy |
| AK Scientific | 9880BB | 2-(Difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | 1333222-12-0 | 250mg | $816 | 2021-12-16 | Buy |
2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Chemical Properties,Uses,Production
Synthesis
1054483-78-1
1895-39-2
1333222-12-0
2-Hydroxypyridine-5-boronic acid pinacol ester (300 mg, 1.357 mmol), sodium difluorochloroacetate (320 mg, 2.036 mmol), and acetonitrile (5 mL) were sequentially added to a sealed reaction tube to form a suspension. The reaction mixture was heated to 80 °C and continuously stirred overnight. After completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated. The target compound 2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (197 mg, 53% yield) was purified by rapid chromatography on silica gel column (eluent: dichloromethane/methanol, 95/5). Mass spectrometry result: m/z 272.8 [M + H]+, retention time (Method 6): 3.12 min.
References
[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 49
[2] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0859-0860
2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-(difluoromethoxy)-5-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7892 | 64 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4566 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 13681763483 | product02@bidepharm.com | China | 39966 | 60 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | triz-4@trizpharma.cn | China | 1936 | 56 |
