NVP-AEW541 (hydrochloride)
- CAS No.
- 2320261-63-8
- Chemical Name:
- NVP-AEW541 (hydrochloride)
- Synonyms
- AEW541 HCl;NVP-AEW541 (hydrochloride);7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine,dihydrochloride
- CBNumber:
- CB52591882
- Molecular Formula:
- C27H30ClN5O
- Molecular Weight:
- 476.02
- MDL Number:
- MOL File:
- 2320261-63-8.mol
- MSDS File:
- SDS
NVP-AEW541 (hydrochloride) price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 500μg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 1mg | $129 | 2026-04-30 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 5mg | $481 | 2026-04-30 | Buy |
| Cayman Chemical | 13641 | NVP-AEW541 (hydrochloride) ≥98% | 2320261-63-8 | 10mg | $842 | 2026-04-30 | Buy |
| Biosynth | VSD26163 | Nvp-aew541 hydrochloride | 2320261-63-8 | 5mg | $1091.55 | 2026-06-05 | Buy |
NVP-AEW541 (hydrochloride) Chemical Properties, Uses, Production
Description
AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP- AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. Note: AEW541 has a Cis-configuration on the cyclobutane ring. Its CAS# is 475489-16-8. Many vendors and Sc-finder scholar made mistake - AEW541 was mistakenly listed as CAS#475488-34-7, the trans-isomer of AEW541. The correct structure of AEW541 can be confirmed from Joel Slade, et al (from Novartis), Org. Process Res. Dev. 2007, 11, 5, 825–835.
Uses
NVP-AEW541 dihydrochloride (AEW541 dihydrochloride) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 dihydrochloride also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 dihydrochloride has antitumor activity[1].
References
[1] García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5(3):231-9. DOI:10.1016/s1535-6108(04)00051-0
NVP-AEW541 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-AEW541 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
