1-(DiMethylsulfaMoyl)pyrazole
- CAS No.
- 133228-21-4
- Chemical Name:
- 1-(DiMethylsulfaMoyl)pyrazole
- Synonyms
- N,N-dimethyl-1H-Pyrazole-1-sulfonamide;1-(DiMethylsulfaMoyl)pyrazole;N,N-dimethylpyrazole-1-sulfonamide;1-(N,N-diMethyl-sulfaMoyl)pyrazole;1H-Pyrazole-1-sulfonamide, N,N-dimethyl-;N,N-dimethyl-1H-pyrazole-1-sulfonamide 97%
- CBNumber:
- CB52597415
- Molecular Formula:
- C5H9N3O2S
- Molecular Weight:
- 175.21
- MDL Number:
- MFCD11865226
- MOL File:
- 133228-21-4.mol
- MSDS File:
- SDS
| Melting point | 118.5 °C |
|---|---|
| Boiling point | 287.4±23.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -2.65±0.12(Predicted) |
| Appearance | Colorless to light yellow Solid-Liquid Mixture |
| InChI | InChI=1S/C5H9N3O2S/c1-7(2)11(9,10)8-5-3-4-6-8/h3-5H,1-2H3 |
| InChIKey | RFYSRCRZAGKOIY-UHFFFAOYSA-N |
| SMILES | N1(S(N(C)C)(=O)=O)C=CC=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
1-(DiMethylsulfaMoyl)pyrazole price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IFA22821 | 1-(Dimethylsulfamoyl)pyrazole | 133228-21-4 | 10g | $472 | 2026-06-04 | Buy |
| Biosynth | IFA22821 | 1-(Dimethylsulfamoyl)pyrazole | 133228-21-4 | 100g | $2360 | 2026-06-04 | Buy |
| Activate Scientific | AS8539 | N,N-Dimethyl-sulfomyl-pyrazole 97% | 133228-21-4 | 1g | $43 | 2026-06-04 | Buy |
| Activate Scientific | AS8539 | N,N-Dimethyl-sulfomyl-pyrazole 97% | 133228-21-4 | 5g | $167 | 2026-06-04 | Buy |
| Activate Scientific | AS8539 | N,N-Dimethyl-sulfomyl-pyrazole 97% | 133228-21-4 | 25g | $523 | 2026-06-04 | Buy |
1-(DiMethylsulfaMoyl)pyrazole Chemical Properties, Uses, Production
Synthesis
288-13-1
13360-57-1
133228-21-4
The general procedure for the synthesis of 1-(N,N-dimethyl-sulfonyl)pyrazole from pyrazole and N,N-dimethylaminosulfonyl chloride is as follows: Example 80: Synthesis of 2-amino-1-(4-chlorophenyl)-1-[4-(3-ethyl-1H-pyrazol-4-yl)phenyl]ethanol Step 80A: Preparation of pyrazole-1-sulfonic acid dimethylamide To a solution of pyrazole (4.8 g, 81.9 mmol) in acetonitrile (125 mL) was sequentially added 1,4-diazabicyclo[2.2.2]octane (DABCO, 10.1 g, 90.3 mmol) and N,N-dimethanaminosulfonyl chloride (8.8 mL, 82.9 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was concentrated in vacuum and the residue was partitioned with water and ethyl acetate. The organic layer was separated, washed sequentially with 2N hydrochloric acid and saturated brine, and dried over anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to afford 1-(N,N-dimethyl-sulfonyl)pyrazole as a colorless oil (13.1 g, 91% yield). LC/MS (PS-A2) retention time 2.16 min, [M+H]+ 176.
References
[1] Synthesis, 2006, # 5, p. 793 - 798
[2] Chemistry - An Asian Journal, 2015, vol. 10, # 8, p. 1626 - 1630
[3] Advanced Synthesis and Catalysis, 2014, vol. 356, # 7, p. 1555 - 1561
[4] Patent: WO2006/136830, 2006, A1. Location in patent: Page/Page column 190-191
[5] Patent: WO2006/136829, 2006, A2. Location in patent: Page/Page column 129
1-(DiMethylsulfaMoyl)pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai SPAR pharmaceutical technology co., LTD | 021-000000 | admin@jingshipharmatech.com | China | 9990 | 58 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2333 | 55 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Mashilabs (Shanghai) Co.,Ltd. | 19916721580 | mafarm@126.com | China | 4532 | 58 |
| Hangzhou J&H Chemical Co., Ltd. | 0571-87396432 | sales@jhechem.com | China | 14877 | 59 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Zhengzhou Guancheng Laboratory equipment Sales | 0371-88888888 qq272369594;2159423853qq | 2723695949@qq.com | China | 4991 | 50 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
